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Investigation of the relationship between chronic montelukast treatment, asthma and depression-like behavior in mice.
Author: BozkurtTurgut Emrah, NemutluEmirhan, OnderSevgen, TelBanu Cahide, TelliGokcen
Original Abstract of the Article :
In 2008, the Food and Drug Administration of the US issued a warning about the neuropsychiatric side effects of montelukast. Previous clinical studies on montelukast have reported conflicting results and, to the best of our knowledge, no experimental studies concerning these side effects had been co...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690246/
データ提供:米国国立医学図書館(NLM)
Montelukast and Depression: A Look at the Link
This research investigates the potential link between montelukast, a medication commonly used to treat asthma, and depression-like behavior in mice. The authors examined whether chronic montelukast treatment in a mouse model of asthma influenced the development of depression-like symptoms.
Imagine a group of camels navigating the desert, some of them burdened by a persistent cough, a sign of asthma. This research explores whether a medication commonly used to treat this cough, montelukast, might have unintended consequences for the camel's mood and well-being.
No Evidence of a Direct Link
The research found that chronic montelukast treatment did not induce depression-like behavior in mice. However, the study also revealed that asthma itself was associated with increased depression-like behavior in the mice. This finding suggests that the relationship between asthma and depression may be more complex than previously thought.
Further Exploration Needed
This research underscores the importance of continued investigation into the potential neuropsychiatric effects of montelukast. While the study did not find a direct link between montelukast and depression in mice, further research is needed to fully understand the complex interplay between asthma, medication, and mood.
Dr.Camel's Conclusion
This research highlights the need to carefully consider the potential side effects of medications, even those used to treat common conditions like asthma. It's a reminder that the desert of human health is complex and interconnected, and we need to continue exploring these connections to ensure the well-being of our patients.
Date :
- Date Completed n.d.
- Date Revised 2020-12-07
Further Info :
Related Literature
English
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