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To study impact of treatment with Rosuvastatin versus Atorvastatin on 25 hydroxy Vitamin D concentrations among adult Indian men- a randomized control trial.

Author: ChiplonkarShashi A, KhadilkarAnuradha V, KhadilkarVaman V, MughalZulf M, PadidelaRaja, PatwardhanVivek G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This randomized, open-label study of 104 Indian men with dyslipidemia evaluated the effects of atorvastatin and rosuvastatin on 25-hydroxyvitamin D (25OHD) levels. Atorvastatin treatment significantly reduced 25OHD levels, while rosuvastatin did not. The reduction in LDL-C concentrations associated with atorvastatin was correlated with 25OHD levels, suggesting a possible relationship between vitamin D status and statin efficacy.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Dyslipidemias are on the rise and are increasingly being treated with statins. As the metabolism of cholecalciferol and cholesterol are interrelated, reduction in cholesterol synthesis by statins is likely to affect Vitamin D status. OBJECTIVES: (1) The aim is to study the effect of tre...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025761/

データ提供：米国国立医学図書館（NLM）

Statins and Vitamin D: Investigating the Interplay of Cholesterol and Vitamin D

In the realm of health, the intricate interplay of various nutrients is a fascinating and complex topic, much like the intricate web of life found within a desert ecosystem. This study, published in the journal Lipids in Health and Disease, investigates the impact of statin treatment on 25-hydroxy Vitamin D (25OHD) concentrations among adult Indian men with dyslipidemia. The researchers conducted a randomized controlled trial to compare the effects of atorvastatin and rosuvastatin on 25OHD levels. This research provides valuable insights into the potential interactions between statins and Vitamin D metabolism, informing clinical practice and personalized medicine.

A Balancing Act: Statins and Vitamin D

The study found that atorvastatin treatment significantly reduced 25OHD concentrations, while rosuvastatin did not have a significant impact. The researchers also observed a correlation between 25OHD levels and the efficacy of atorvastatin in reducing LDL-C concentrations. These findings suggest a complex interplay between statin treatment and Vitamin D metabolism, highlighting the importance of monitoring Vitamin D levels in patients receiving statin therapy.

A Desert Oasis of Nutrients

Imagine a desert oasis where the delicate balance of nutrients is crucial for maintaining life. This research highlights the importance of understanding the interconnectedness of different nutrients within the body. By recognizing the potential interactions between statins and Vitamin D, we can make informed decisions about medication management and ensure optimal health for individuals receiving statin therapy.

Dr.Camel's Conclusion

The desert of health is full of surprising interactions. This research reminds us to look beyond individual nutrients and consider the intricate interplay of various factors that contribute to overall health and well-being. By understanding these complex relationships, we can make informed decisions about our health and create a more sustainable and balanced ecosystem within ourselves.

Date :
  1. Date Completed 2021-11-22
  2. Date Revised 2022-04-18
Further Info :

Pubmed ID

33283767

DOI: Digital Object Identifier

PMC8025761

SNS
PICO Info
in preparation
Languages

English

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