Subgroup analysis by prior anti-VEGF or anti-EGFR target therapy in FRESCO, a randomized, double-blind, Phase III trial.

Author: BaiYuxian, CaoPeiguo, ChenDonghui, ChenHaihui, ChenZhendong, ChengYing, DengYanhong, GuoWeijian, GuoXiaojun, HanRubing, LiJian, LiJin, LiWei, LiuTianshu, MaDong, PanHongming, QinShukui, ShuYongqian, SuWeiguo, SunSanyuan, WangHongbing, WangJiejun, WangNing, WangShubin, WuChangping, XuJianming, XuNong, XuRuihua, YangLei, YuZhuang, YuanYing, ZhangBin, ZhongHaijun, ZhouJianfeng

Paper Details 
Original Abstract of the Article :
<b>Background:</b> FRESCO study demonstrated efficacy and safety of fruquintinib in metastatic colorectal cancer&#160;patients. Impact of prior targeted therapy (PTT) on efficacy and safety of fruquintinib was evaluated. <b>Materials &amp; methods:</b> In this subgroup analysis of FRESCO trial, pat...See full text at original site
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引用元:
https://doi.org/10.2217/fon-2020-0875

データ提供:米国国立医学図書館(NLM)

Subgroup Analysis by Prior Anti-VEGF or Anti-EGFR Target Therapy in FRESCO, a Randomized, Double-Blind, Phase III Trial

As a researcher in the realm of oncology, I find the quest for effective treatments for metastatic colorectal cancer particularly captivating. This study focuses on the efficacy and safety of fruquintinib, a drug that holds promise in this fight. The authors conducted a subgroup analysis of the FRESCO trial, examining the impact of prior targeted therapy (PTT) on the effectiveness of fruquintinib. The results demonstrate that fruquintinib significantly improved overall survival and progression-free survival in both patients with and without prior targeted therapy, highlighting its potential as a valuable treatment option for a wider range of patients.

A Oasis of Hope in the Desert of Metastatic Colorectal Cancer

The findings of this study suggest that fruquintinib may be a beacon of hope in the challenging landscape of metastatic colorectal cancer. This study provides evidence that fruquintinib demonstrates significant improvements in overall survival and progression-free survival, regardless of prior targeted therapy. This promising outcome could potentially broaden the treatment options available to a larger patient population, offering a ray of light in the midst of the disease's relentless journey.

Navigating the Path Towards Better Treatments

This study is an important step in our collective journey towards finding better treatments for metastatic colorectal cancer. The findings suggest that fruquintinib could offer a valuable treatment option for a broader range of patients, potentially easing the burden of this formidable disease. By exploring the diverse aspects of treatment response, including the impact of prior targeted therapy, we can refine our understanding of this complex disease and work towards developing more targeted and effective therapies.

Dr. Camel's Conclusion

This study provides encouraging evidence that fruquintinib holds promise as a valuable treatment option for metastatic colorectal cancer, regardless of prior targeted therapy. This research provides a valuable step towards understanding the nuances of treatment response in this challenging disease and offers hope for a brighter future for patients facing this formidable illness.

Date :
  1. Date Completed 2021-10-29
  2. Date Revised 2022-07-01
Further Info :

Pubmed ID

33325251

DOI: Digital Object Identifier

10.2217/fon-2020-0875

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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