Early Combined Immunosuppression Reduces Complications in Long-standing Crohn's Disease: A Post Hoc Analysis of REACT.

Author: D'HaensGeert R, DulaiParambir S, FeaganBrian G, HanzelJurij, JairathVipul, MaChristopher, SandbornWilliam J, SinghSiddharth, ZouGuangyong

Paper Details 
Original Abstract of the Article :
Crohn's disease (CD) can lead to bowel damage, stricturing, and obstruction thereby resulting in surgery and hospitalization. The Randomized Evaluation of an Algorithm for Crohn's Treatment (REACT) trial showed that early combined immunosuppression (ECI) with symptom-based treatment escalation for 2...See full text at original site
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引用元:
https://doi.org/10.1016/j.cgh.2020.12.019

データ提供:米国国立医学図書館(NLM)

Early Intervention: A Key to Managing Crohn's Disease

Crohn's disease, a chronic inflammatory bowel disease, can be a challenging journey through the desert of digestive discomfort. This research explores the potential benefits of early combined immunosuppression (ECI) in managing this condition. The authors delve into the findings of the Randomized Evaluation of an Algorithm for Crohn's Treatment (REACT) trial, which demonstrated that ECI, implemented early in the disease course, significantly reduced the risk of surgery, hospitalization, and Crohn's-related complications compared to conventional management (CM).

Preventing Complications: The Importance of Early Treatment

This research, like a carefully crafted oasis in the desert, highlights the importance of early intervention in managing Crohn's disease. The authors, based on the REACT trial results, suggest that treating Crohn's disease earlier in its progression could be a key to preventing serious complications and improving long-term outcomes for patients. This finding underscores the crucial role of timely diagnosis and intervention in managing chronic diseases.

A Paradigm Shift: From Reactive to Proactive Management

This research advocates for a paradigm shift in Crohn's disease management, moving away from a reactive approach that focuses on treating symptoms as they arise to a proactive strategy that aims to prevent complications from the outset. It's a reminder that a proactive approach, much like a well-planned journey through the desert, can significantly improve the overall health and well-being of patients.

Dr. Camel's Conclusion

This research, like a beacon of hope in the desert of Crohn's disease, underscores the importance of early intervention in managing this chronic condition. The authors highlight the potential of ECI to reduce complications and improve long-term outcomes, encouraging a proactive approach to patient care. This research serves as a valuable reminder that early intervention can have a profound impact on the course of chronic diseases, potentially improving the lives of patients and reducing the burden on the healthcare system.
Date :
  1. Date Completed 2022-03-15
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

33346141

DOI: Digital Object Identifier

10.1016/j.cgh.2020.12.019

SNS
PICO Info
in preparation
Languages

English

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