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Dose-dependent effects of antipsychotics on efficacy and adverse effects in schizophrenia.

Author: TakeuchiHiroyoshi, YoshidaKazunari

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This narrative review summarizes current evidence on the dose-response relationship of antipsychotics in patients with schizophrenia. The review found that the efficacy of antipsychotics generally appeared to be highly dose-dependent in the acute phase of schizophrenia. The relationship between dose and adverse effects varied, with some being dose-related and others showing mixed findings. The review highlights the importance of balancing risks and benefits when optimizing antipsychotic treatment in patients with schizophrenia.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Antipsychotics are a cornerstone of pharmacological treatment of schizophrenia. Improved understanding of the dose-response relationship of antipsychotics in terms of efficacy, adverse effects, and mortality can help to optimize the pharmacological treatment of schizophrenia. METHODS: T...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbr.2020.113098

データ提供：米国国立医学図書館（NLM）

Antipsychotics: Balancing Efficacy and Adverse Effects in Schizophrenia Treatment

The field of psychiatry is constantly striving to improve treatments for schizophrenia, a complex and often debilitating mental illness. This review delves into the dose-response relationship of antipsychotics in treating schizophrenia, highlighting the critical balance between efficacy and potential side effects.

Antipsychotic Dose: A Delicate Balancing Act

The review revealed that the efficacy of antipsychotics in the acute phase of schizophrenia is generally dose-dependent, each drug exhibiting a unique dose-response curve. However, the relationship between dose and adverse effects is more complex, with some side effects being dose-related and others less predictable. This complex interplay, like a camel navigating a shifting desert landscape, requires careful consideration when tailoring antipsychotic treatment for individual patients.

Navigating the Risks and Benefits

Understanding the dose-response relationship of antipsychotics is essential for optimizing treatment in schizophrenia. It allows clinicians to balance the potential benefits of antipsychotics with the risks of adverse effects. This approach, like a skilled camel driver choosing the safest route through a challenging desert, ensures that patients receive the most effective treatment while minimizing potential harm.

Dr. Camel's Conclusion

This review, like a desert guidebook offering insights into the complex terrain of schizophrenia treatment, emphasizes the importance of understanding the dose-response relationship of antipsychotics. It's a reminder that even seemingly simple interventions can have complex consequences, requiring a careful approach to ensure patient safety and well-being.
Date :
  1. Date Completed 2021-12-27
  2. Date Revised 2021-12-27
Further Info :

Pubmed ID

33417992

DOI: Digital Object Identifier

10.1016/j.bbr.2020.113098

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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