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Systematic Review of Time to Definitive Treatment for Intermediate Risk and High Risk Prostate Cancer: Are Delays Associated with Worse Outcomes?

Author: CelliniJacqueline, ChoudhuryAtish D, ConeEugene B, HaeuserLorine, KibelAdam S, LipsitzStuart R, NguyenDavid-Dan, PaciottiMarco, ReitblatChanan, TrinhQuoc-Dien

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Prostate cancer is often slow-growing, especially when detected early. While delaying treatment for low-risk prostate cancer is generally considered acceptable, the impact of delaying treatment for intermediate and high-risk prostate cancer is less clear. This study investigated whether delaying treatment for these more aggressive forms of prostate cancer negatively affects outcomes.
Paper Details　
Original Abstract of the Article :
Prostate cancer is most commonly an indolent disease, especially when detected at a localized stage. Unlike other tumors that may benefit from timely receipt of definitive therapy, it is generally accepted that treatment delays for localized prostate cancer are acceptable, especially for low risk pr...See full text at original site
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引用元：
https://doi.org/10.1097/JU.0000000000001601

データ提供：米国国立医学図書館（NLM）

Delays in Prostate Cancer Treatment: A Complex Issue

Prostate cancer is a common cancer that often progresses slowly, especially in its early stages. Researchers in the field of oncology are continually investigating the optimal treatment approaches for prostate cancer, aiming to balance effectiveness with minimal side effects. This systematic review explores the controversial issue of treatment delays for intermediate and high-risk prostate cancer, examining whether such delays negatively impact oncological outcomes.

Navigating the Complexities of Treatment Decisions

This systematic review highlights the complex nature of treatment decisions for prostate cancer, recognizing that delays may be acceptable for low-risk disease but more controversial for intermediate and high-risk cases. The review examined existing studies to assess the impact of treatment delays on oncological outcomes for these higher-risk groups. While the evidence is mixed, the review suggests that in some cases, delays may be associated with worse outcomes, underscoring the importance of careful assessment and timely intervention for these patients.

Implications for Prostate Cancer Management

This review's findings have important implications for prostate cancer management, highlighting the need for careful consideration of individual patient factors, including their risk profile, when determining the optimal treatment approach. The review emphasizes the importance of ongoing research to clarify the impact of treatment delays on oncological outcomes for different risk groups. By understanding the potential risks and benefits associated with delays, clinicians can make more informed decisions about treatment timing, ultimately aiming to improve patient outcomes and minimize the risk of disease progression.

Dr.Camel's Conclusion

This systematic review is like a caravan crossing a desert landscape, revealing the complexities of prostate cancer treatment and the importance of carefully navigating the terrain of treatment decisions. It underscores the need for further research to better understand the impact of delays on different risk groups, enabling clinicians to make more informed decisions and improve patient outcomes.

Date :
  1. Date Completed 2021-07-15
  2. Date Revised 2021-07-15
Further Info :

Pubmed ID

33443458

DOI: Digital Object Identifier

10.1097/JU.0000000000001601

Related Literature

Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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