Tizanidine versus baclofen in the treatment of spasticity in patients with multiple sclerosis.

Author: BassB, BouchardS, CameronM G, EbersG C, HaderW, NoseworthyJ H, RiceG P, WeinshenkerB

Paper Details 
Original Abstract of the Article :
Tizanidine (Sirdalud) was compared to baclofen (Lioresal) in a randomized, double-blind, cross-over trial. Each medication was introduced over a three week titration period and then maintained at the highest tolerated dose for five weeks. The two treatment phases were separated by a one week drug wi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1017/s0317167100027104

データ提供:米国国立医学図書館(NLM)

Tizanidine vs. Baclofen: Which Camel is Better Suited for the Journey?

Spasticity, a common complication of multiple sclerosis (MS), can make life feel like a journey through a desert with obstacles hindering your progress. This research compares two common medications, tizanidine and baclofen, used to manage spasticity. Think of these medications as two different camels, each with its strengths and weaknesses, guiding you through the desert of MS.

Comparing the Two Camels

The study found that both tizanidine and baclofen can be beneficial in managing spasticity in MS patients. While baclofen was perceived to be more effective and well-tolerated by neurologists and physiotherapists, the difference was not statistically significant. However, baclofen was found to cause more muscle weakness, whereas tizanidine was associated with somnolence and dry mouth. It's like choosing a camel for your journey: one might be stronger but less agile, while the other might be faster but less reliable.

Choosing the Right Camel

The choice between tizanidine and baclofen ultimately depends on the individual patient's needs and preferences. Factors such as side effects, tolerance, and specific symptoms need to be considered carefully. It's a matter of finding the right camel for the specific terrain of your MS journey, one that will help you overcome the obstacles and reach your destination.

Dr.Camel's Conclusion

This research offers valuable insights into the management of spasticity in MS, comparing the effectiveness and side effects of two common medications. Finding the right approach, like choosing the right camel, is crucial for a smooth and successful journey through the desert of MS.

Date :
  1. Date Completed 1988-04-21
  2. Date Revised 2019-08-28
Further Info :

Pubmed ID

3345456

DOI: Digital Object Identifier

10.1017/s0317167100027104

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.