Epidemiology of Intussusception Hospitalizations in Children Under 2 Years of Age Post Rotavirus Vaccine Introduction in Tamil Nadu and Puducherry, India.

Author: DorairajPriyadarshini, GuruswamyRajamani, KulandaivelM, KumarB Hemanth, KumarC P Girish, KumaranJ Muthu, KumaravelS, ManiamRaghul, NSamarasimha Reddy, RamasubramaniamP, SelvarajanNamasivayam, ShenoyAswitha, SubramanianSenthilnathan, SundaramBalasubramanian, ThiyagarajanVarunkumar

Paper Details 
Original Abstract of the Article :
High burden of rotavirus associated diarrhea has been documented among Indian children. The phased introduction of an indigenous rotavirus vaccine 'ROTAVAC' in India's national immunization programme began in 2017. Phase-III trial showed the vaccine to have a low-intussusception-risk profile. Howeve...See full text at original site
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引用元:
https://doi.org/10.1007/s12098-020-03597-1

データ提供:米国国立医学図書館(NLM)

Rotavirus Vaccine and Intussusception

The introduction of vaccines is a major triumph in medicine, like finding a fertile oasis in a vast desert. However, it's crucial to continuously monitor the potential side effects of vaccines to ensure their safety and efficacy. This study explored the epidemiology of intussusception, a condition where a portion of the intestine telescopes into itself, in children under two years of age in Tamil Nadu and Puducherry, India, following the introduction of a rotavirus vaccine called 'ROTAVAC'. Researchers analyzed hospitalization data to assess the potential risk of vaccine-associated intussusception.

ROTAVAC's Safety Profile: A Desert Oasis

The study found that while intussusception hospitalization rates increased following the introduction of ROTAVAC, the overall rate remained low compared to other regions. This suggests that the vaccine's safety profile is generally good, but further investigation is needed to determine if there is any correlation between the vaccine and intussusception. This is like finding an oasis in the desert, but ensuring its safety and sustainability requires further investigation.

Post-licensure Surveillance: Ensuring Safety and Efficacy

This study highlights the importance of post-licensure surveillance for vaccines. It's crucial to monitor the long-term impact of vaccines on public health, like maintaining the delicate balance of an ecosystem in a desert. This helps ensure that vaccines remain safe and effective over time, providing a beacon of hope for the health of future generations.

Dr. Camel's Conclusion

This study emphasizes the importance of ongoing vigilance in monitoring the safety of vaccines. While the introduction of ROTAVAC has been a positive step, further research is needed to fully understand its potential effects. By continuously analyzing data and investigating any potential associations, we can ensure the safety and efficacy of vaccines, protecting the health of individuals and populations alike. This is like tending to a desert garden, nurturing its growth and ensuring its long-term sustainability.

Date :
  1. Date Completed 2021-05-25
  2. Date Revised 2021-05-25
Further Info :

Pubmed ID

33469897

DOI: Digital Object Identifier

10.1007/s12098-020-03597-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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