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A Phase 2 Randomized Trial of DCL-101, a Novel Pill-Based Colonoscopy Prep, vs 4L Polyethylene Glycol-Electrolyte Solution.

Author: BachwichDale R, CalderwoodAudrey H, JacobsonBrian C, KochmanMichael L, KowalVera O, LewisJames D

Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

DCL-101 is a new type of pill preparation for colonoscopy. This study compared the safety, taste, and tolerability of DCL-101 with standard PEG-ELS. DCL-101 was found to be safe, well-tolerated, and tasted better than the standard solution.
Paper Details　
Original Abstract of the Article :
DCL-101, a novel Pill Prep, is compositionally identical to standard 4L polyethylene glycol-electrolyte solution (PEG-ELS) and delivers the salt encapsulated, with PEG 3350 coadministered as a taste-free oral solution. The aim of this study was to compare the safety, taste, and tolerability of DCL-1...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678801/

データ提供：米国国立医学図書館（NLM）

A Novel Pill-Based Colonoscopy Prep: A Camel's Journey Through the Desert of Bowel Prep

Colonoscopy is a vital procedure for detecting and preventing colorectal cancer, but the preparation process is often perceived as unpleasant. This study explores the potential of a novel pill-based colonoscopy prep, DCL-101, which aims to improve the tolerability of this crucial step. The researchers conducted a phase 2 randomized trial, comparing the safety, taste, and tolerability of DCL-101 with the standard 4L polyethylene glycol-electrolyte solution (PEG-ELS), a common bowel preparation solution.

A Smooth Ride Through the Desert: A Camel's Experience

The study found that DCL-101 was comparable to 4L PEG-ELS in terms of safety, taste, and tolerability. This finding suggests that DCL-101 may offer a more comfortable alternative for patients undergoing colonoscopy. The researchers also assessed the efficacy of DCL-101, finding that it performed well in preparing patients for the procedure. These results are encouraging and highlight the potential of DCL-101 as a promising new option for bowel preparation.

A Camel's Guide to Colonoscopy Prep: Navigating the Dunes with Ease

Preparing for a colonoscopy can be a challenging experience, but advancements in bowel preparation methods are making this process more tolerable. DCL-101 is a novel pill-based solution that has shown promising results in terms of safety, taste, and efficacy. If you are scheduled for a colonoscopy, discuss the available bowel preparation options with your doctor to find the best solution for your individual needs.

Dr. Camel's Conclusion

This study provides a ray of hope for patients undergoing colonoscopy. DCL-101, a novel pill-based prep, offers a potentially more comfortable and palatable alternative to traditional bowel preparation solutions. While further research is needed, this study suggests that DCL-101 may significantly improve the patient experience, leading to a smoother journey through the desert of colonoscopy preparation.

Date :
  1. Date Completed 2021-07-15
  2. Date Revised 2022-10-05
Further Info :

Pubmed ID

33512795

DOI: Digital Object Identifier

PMC7678801

Related Literature

Article Analysis
・Effects of polyethylene glycol 3350
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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