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Disease stability and extended dosing under anti-VEGF treatment of exudative age-related macular degeneration (AMD) - a meta-analysis.

Author: GarwegJustus G, GerhardtChristin

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This meta-analysis of 29 studies found that disease stability was achieved in 62.9% of eyes after 12 months of treatment with ranibizumab, aflibercept, or brolucizumab for exudative age-related macular degeneration (AMD). However, the proportion of eyes achieving disease stability decreased to 56.0% after 24 months. The proportion of eyes that could extend their treatment interval to ≥ 12 weeks increased from 37.7% to 42.6% after 24 months.
Paper Details　
Original Abstract of the Article :
PURPOSE: To assess disease stability (absence of intra- and/or subretinal fluid) and the portion of eyes being capable to extend their treatment interval to ≥ 12 weeks in exudative age-related macular degeneration (AMD). METHODS: A systematic literature search was performed in NCBI, PubMed, CENTRAL...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352813/

データ提供：米国国立医学図書館（NLM）

Anti-VEGF Treatment for Exudative Age-Related Macular Degeneration: Navigating the Desert of Disease Stability

Exudative age-related macular degeneration (AMD), a leading cause of vision loss, presents a significant challenge for ophthalmologists. This study delves into the long-term effects of anti-VEGF treatment for AMD, utilizing [research methods] to assess disease stability and the ability to extend treatment intervals. The researchers found that [research findings] in patients receiving anti-VEGF treatment for exudative AMD.

A Shifting Sandscape: Disease Stability and Treatment Intervals

The study reveals a dynamic landscape in the management of exudative AMD. The researchers observed that while disease stability was initially achieved in a significant portion of patients, this stability tended to decrease over time. This suggests that maintaining disease control in the long term may require ongoing adjustments and modifications to treatment strategies. The study also found that a significant portion of patients were able to extend their treatment intervals to 12 weeks or more, reflecting the potential for reduced treatment burden and improved patient convenience.

A Journey Through the Desert: Managing Exudative AMD

The study underscores the need for careful monitoring and ongoing adjustments in the management of exudative AMD. The research suggests that maintaining disease stability may require a dynamic approach, akin to navigating a constantly shifting desert landscape. The study's findings emphasize the importance of balancing the need for effective treatment with the desire for reduced treatment burden, allowing for individualized care that meets the unique needs of each patient.

Dr. Camel's Conclusion

This study provides valuable insights into the long-term effects of anti-VEGF treatment for exudative age-related macular degeneration. The findings highlight the importance of ongoing monitoring and adjustments to treatment strategies to maintain disease stability. The study underscores the importance of individualized care and the need to balance effective treatment with reduced treatment burden.

Date :
  1. Date Completed 2021-08-18
  2. Date Revised 2022-11-02
Further Info :

Pubmed ID

33528645

DOI: Digital Object Identifier

PMC8352813

Related Literature

Article Analysis
・Effective treatment of macular degeneration
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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