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Acthar® Gel (repository corticotropin injection) dose-response relationships in an animal model of epileptic spasms.

Author: FrostJames D, LeJohn T, SwannJohn W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Repository corticotropin injection (RCI) effectively suppressed spasms in a tetrodotoxin (TTX) model of early-life-induced epileptic spasms in rats. RCI eliminated spasms in 66% of animals treated with 24 or 32 IU/kg/day. The drug also eliminated abnormal interictal EEG activity in rats that became seizure-free. RCI-induced corticosterone release increased linearly with increasing dosages, suggesting that very high concentrations of circulating corticosteroids might be needed to abolish spasms or that RCI acts through a different mechanism.
Paper Details　
Original Abstract of the Article :
Studies were undertaken to evaluate the effectiveness of Acthar® Gel (repository corticotropin injection [RCI]) in the tetrodotoxin (TTX) model of early-life-induced epileptic spasms. Repository corticotropin injection (RCI) is widely used in the United States to treat infantile spasms. A major comp...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/33548914

データ提供：米国国立医学図書館（NLM）

Acthar® Gel (Repository Corticotropin Injection) Dose-Response Relationships in an Animal Model of Epileptic Spasms

Infantile spasms, a severe form of epilepsy, are a challenging condition to treat. This research investigates the effectiveness of Acthar® Gel (repository corticotropin injection [RCI]), a medication commonly used for infantile spasms, in an animal model of epileptic spasms. The study aimed to determine the dose-response relationship of RCI in reducing spasm frequency and to explore the role of circulating corticosteroids in spasm cessation.

Effective at High Doses: RCI and Epileptic Spasm Suppression

The study found that RCI effectively suppressed spasms in rats at high dosages (24 or 32 IU/kg/day). Lower doses were ineffective. The researchers also observed that RCI significantly reduced hypsarrhythmia-like activity, an abnormal interictal EEG pattern associated with infantile spasms. These findings provide evidence for the efficacy of RCI in reducing spasm frequency and abnormal brain activity in this animal model.

Potential for Improved Treatment: Implications for Infantile Spasms

This research contributes to our understanding of the potential benefits of RCI in treating infantile spasms. The study highlights the importance of finding the appropriate dose of RCI to achieve maximal therapeutic effects. Further research is needed to confirm these findings in human clinical trials and to explore the potential for optimizing RCI treatment regimens for infantile spasms.

Dr. Camel's Conclusion

My dear friends, imagine a desert storm, a chaotic and relentless force that can leave a trail of destruction. This study is like a beacon of hope amidst the storm of infantile spasms, offering potential relief through the use of RCI. While more research is needed to fully understand the mechanisms of action and optimal dosing, the study provides valuable insights into the potential of RCI as a therapeutic agent for this debilitating condition. It's a reminder that even in the most challenging situations, there is always hope for a brighter future.
Date :
  1. Date Completed 2021-04-20
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

33548914

DOI: Digital Object Identifier

NIHMS1664462

Related Literature

Article Analysis
・Effects of corticotropin repository injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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