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One year of procarbazine lomustine and vincristine is poorly tolerated in low grade glioma: a real world experience in a national neuro-oncology centre.

Author: AslamRazia, BreathnachOscar S, CoyneZac, GroganLiam, HennessyBryan T, HennessyMaeve A, KeoghRachel J, MorrisPatrick G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

PCV chemotherapy is an effective adjuvant therapy for low-grade glioma, but its tolerability in routine clinical practice is not well understood.
Paper Details　
Original Abstract of the Article :
Following optimal local therapy, adjuvant Procarbazine, Lomustine and Vincristine (PCV) improves overall survival (OS) in low-grade glioma (LGG). However, 1 year of PCV is associated with significant toxicities. In the pivotal RTOG 9802 randomised control trial, approximately half of the patients di...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869199/

データ提供：米国国立医学図書館（NLM）

The Challenges of Procarbazine Lomustine and Vincristine (PCV) Chemotherapy for Low-Grade Glioma

[Low-grade glioma (LGG)] treatment is a complex field, constantly seeking new strategies to improve patient outcomes. This research explores the tolerability of [PCV chemotherapy] in routine clinical practice, highlighting the challenges associated with this approach.

PCV Chemotherapy for Low-Grade Glioma: Tolerability in Routine Practice

The study reveals that [PCV chemotherapy] can be associated with [significant toxicities], leading to [treatment discontinuation] in a significant proportion of patients. The authors emphasize the need for careful monitoring and consideration of treatment options based on individual patient circumstances. This research underscores the importance of finding more tolerable treatment regimens for LGG.

Navigating Cancer Treatment: Patient-Centered Approaches

Treating cancer, like navigating a vast desert, requires careful consideration and adaptation. This study emphasizes the importance of patient-centered care, where treatment decisions are made in consultation with the individual patient and their unique needs. By understanding the challenges and complexities of chemotherapy, we can develop better strategies for managing LGG and improving patient outcomes.

Dr. Camel's Conclusion

Cancer treatment can be a long and arduous journey. This study provides valuable insights into the challenges and complexities of [PCV chemotherapy] for LGG, reminding us that finding the right path requires a careful understanding of individual patient needs and the potential side effects of treatment.
Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

33557783

DOI: Digital Object Identifier

PMC7869199

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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