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Comparison of the Inhibitory Effects of Clotrimazole and Ketoconazole against Human Carboxylesterase 2.

Author: ChenJing, DouTongyi, GeGuangbo, LiuKexin, MengQiang, SunHuijun, WangChangyuan, WangDalong, WuJingjing, ZhaoShan, ZhaoTingting

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that clotrimazole, an antifungal agent, strongly inhibited the activity of human liver microsome hCE2, an enzyme involved in the metabolism of several anti-cancer drugs. Ketoconazole also inhibited hCE2, but to a lesser extent.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Both clotrimazole and ketoconazole have been verified to have an inhibitory effect on CYP3A4. hCE2 is an enzyme closely related to the side effects of several anti-cancer drugs. However, the interactions between hCE2, clotrimazole, and ketoconazole remain unclear. OBJECTIVE: The objecti...See full text at original site
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引用元：
https://doi.org/10.2174/1389200222666210210115509

データ提供：米国国立医学図書館（NLM）

Clotrimazole and Ketoconazole: A Comparative Study of Their Inhibitory Effects on Human Carboxylesterase 2

In the vast desert of drug interactions, understanding the effects of different medications on enzyme activity is crucial for patient safety. This research examines the inhibitory effects of clotrimazole and ketoconazole, two antifungal agents, on human carboxylesterase 2 (hCE2), an enzyme closely associated with the side effects of several anti-cancer drugs. The authors compare the inhibitory properties of these two antifungal agents, revealing significant differences in their effects on hCE2 activity.

Clotrimazole: A Potential Agent for Reducing hCE2-Mediated Side Effects

This research, much like a skilled desert navigator, explores the intricacies of drug-enzyme interactions, uncovering the potential of clotrimazole to modulate hCE2 activity. The findings suggest that clotrimazole, compared to ketoconazole, exhibits a stronger inhibitory effect on hCE2, potentially reducing the side effects associated with certain anti-cancer drugs. These findings pave the way for further research into the potential of clotrimazole as a co-administered agent to enhance the efficacy and safety of anti-cancer therapies.

Optimizing Cancer Treatment Strategies

This research, like a shimmering oasis in the desert of drug development, offers valuable insights into optimizing cancer treatment strategies. By understanding the inhibitory effects of various medications on enzymes like hCE2, we can develop more effective and safer therapeutic approaches for cancer patients. This research is a testament to the ongoing quest for better and safer treatments for those battling cancer.

Dr.Camel's Conclusion

This research, much like a camel caravan carrying precious knowledge, reveals the potential of clotrimazole to reduce the side effects associated with certain anti-cancer drugs by inhibiting hCE2 activity. These findings offer a glimmer of hope in the ongoing quest for improved cancer treatments.
Date :
  1. Date Completed 2021-12-28
  2. Date Revised 2021-12-28
Further Info :

Pubmed ID

33568030

DOI: Digital Object Identifier

10.2174/1389200222666210210115509

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Languages

English

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