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Improvement of Gut Diversity and Composition After Direct-Acting Antivirals in Hepatitis C Virus-Infected Patients With or Without Human Immunodeficiency Virus Coinfection.

Author: AvihingsanonAnchalee, CheevadhanarakSupapon, ChirapongsathornSakkarin, ChuaypenNatthaya, JinatoThananya, NookaewIntawat, TanakaYasuhito, TangkijvanichPisit

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that direct-acting antivirals (DAAs) used to treat hepatitis C virus (HCV) infection had a short-term effect on restoring microbial dysbiosis in the gut. The gut microbiota of HCV-infected patients, both with and without HIV coinfection, was less diverse and distinct from healthy controls before treatment. However, after successful treatment, responders experienced improvement in microbial dysbiosis, especially those with low fibrosis. This suggests that DAA treatment may contribute to reducing HCV-related complications.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The influence of direct-acting antivirals (DAAs) on the composition of gut microbiota in hepatitis C virus (HCV)-infected patients with or without human immunodeficiency virus (HIV) is unclear. METHODS: We enrolled 62 patients with HCV monoinfection and 24 patients with HCV/HIV coinfect...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557699/

データ提供：米国国立医学図書館（NLM）

Restoring Microbial Harmony: DAAs and the Gut Microbiota

The human gut is a complex ecosystem, teeming with trillions of bacteria, collectively known as the gut microbiota. This intricate community plays a crucial role in maintaining health, but can be disrupted by disease. Hepatitis C virus (HCV) infection is one such condition that can disrupt the delicate balance of the gut microbiota. This research investigates the impact of direct-acting antivirals (DAAs), a new class of medications for HCV, on gut microbiota composition in patients with or without HIV coinfection. The study employed amplicon-based 16S rRNA sequencing to analyze fecal samples from patients before and after DAA treatment.

DAAs: Reshaping the Gut Microbiota Landscape

The results revealed that DAA treatment led to significant improvements in gut microbiota composition and diversity in patients who achieved sustained virological response. This is like restoring a desert oasis, where the once barren landscape becomes vibrant with life. The study found that the beneficial bacteria increased, while the harmful bacteria decreased, leading to a more balanced and resilient gut microbiota.

Gut Microbiota and HCV Treatment

This research provides evidence that DAAs not only eradicate HCV but also contribute to the restoration of gut microbiota dysbiosis. The findings suggest that targeting the gut microbiota might be a valuable adjunct to HCV treatment, potentially enhancing treatment outcomes and improving long-term health. It's like planting seeds in the desert, nurturing a thriving ecosystem within the gut.

Dr.Camel's Conclusion

This research highlights the intricate connection between HCV infection, the gut microbiota, and DAA treatment. It underscores the importance of considering the gut microbiota in managing HCV and suggests the potential for microbiota-based interventions to enhance treatment outcomes.

Date :
  1. Date Completed 2022-01-13
  2. Date Revised 2022-02-18
Further Info :

Pubmed ID

33598686

DOI: Digital Object Identifier

PMC8557699

SNS
PICO Info
in preparation
Languages

English

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