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Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review.

Author: HeardDaniel S, KennedyBrian K, KioussisBenjamin, LautenschlagerNicola T, MaierAndrea B, TuttleCamilla S L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Dementia is a debilitating syndrome that significantly impacts individuals over the age of 65. Currently, there are no disease-modifying treatments for dementia. Impairment of nutrient sensing pathways has been implicated in the pathogenesis of dementia and may offer a novel treatment approach for dementia.
Paper Details　
Original Abstract of the Article :
Dementia is a debilitating syndrome that significantly impacts individuals over the age of 65 years. There are currently no disease-modifying treatments for dementia. Impairment of nutrient sensing pathways has been implicated in the pathogenesis of dementia, and may offer a novel treatment approach...See full text at original site
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引用元：
https://doi.org/10.1016/j.arr.2021.101302

データ提供：米国国立医学図書館（NLM）

Targeting Impaired Nutrient Sensing in Age-Related Cognitive Decline

This systematic review explores the potential of repurposed therapeutics to prevent or treat age-related cognitive decline and dementia by targeting impaired nutrient sensing pathways. The review highlights the growing body of evidence linking disruptions in nutrient sensing pathways to the pathogenesis of dementia. The researchers suggest that targeting these pathways with repurposed therapeutics could offer a novel approach to tackling this challenging condition. They also acknowledge the need for further research to validate this approach and develop effective treatments.

Repurposed Therapeutics: A New Frontier in Dementia Treatment

This review presents a compelling argument for targeting impaired nutrient sensing pathways as a potential therapeutic strategy for dementia. The concept of repurposing existing drugs for new indications offers a promising avenue for developing effective treatments for this complex disease. However, further research is needed to validate this approach and demonstrate its efficacy in clinical trials.

Navigating the Desert of Cognitive Decline

Imagine a vast desert landscape where cognitive function gradually declines with age, leading to the challenges of dementia. This review, like a skilled desert guide, points towards a potential path for combating this decline by addressing the underlying disruptions in nutrient sensing pathways. The research highlights the need for continued exploration and innovation in the quest for effective dementia treatments.

Dr. Camel's Conclusion

This systematic review highlights the potential of targeting impaired nutrient sensing pathways with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia. While promising, further research is needed to validate this approach and develop effective treatments for this complex and debilitating condition. The review encourages continued exploration and innovation in the quest for effective dementia treatments, offering hope for individuals facing this challenging journey.
Date :
  1. Date Completed 2021-04-19
  2. Date Revised 2021-04-19
Further Info :

Pubmed ID

33609776

DOI: Digital Object Identifier

10.1016/j.arr.2021.101302

Related Literature

Article Analysis
・Effective treatment of dementia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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