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Development and characterization&#160;of lyophilized&#160;cefpodoxime proxetil-Pluronic<sup>&#174;</sup> F127/polyvinylpyrrolidone K30 solid dispersions with improved dissolution and enhanced antibacterial activity.

Author: Yurtdaş-KırımlıoğluGülsel

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed hard-cellulose capsules containing cefpodoxime proxetil loaded solid dispersions for improved antibacterial therapy. The solid dispersions exhibited increased solubility, dissolution rate, and antibacterial effectiveness compared to pure cefpodoxime proxetil.
Paper Details　
Original Abstract of the Article :
The aim of this study was the development of hard-cellulose capsules containing cefpodoxime proxetil (CEF) (BCS Class II) loaded novel Pluronic<sup>&#174;</sup> F127 (P127)/Polyvinylpyrrolidone K30 (PVP) solid dispersions (SDs) using ultrasonic probe induced solvent-lyophilization method for effecti...See full text at original site
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引用元：
https://doi.org/10.1080/10837450.2021.1889584

データ提供：米国国立医学図書館（NLM）

Cefpodoxime Proxetil: A New Formulation for Enhanced Antibacterial Activity

This study explores the development of a novel lyophilized cefpodoxime proxetil (CEF) solid dispersion formulation using Pluronic® F127/Polyvinylpyrrolidone K30 (PVP) for enhanced antibacterial activity. The research demonstrates the improved dissolution rate, reduced particle size, and enhanced wettability of the CEF solid dispersions, leading to increased solubility and improved antibacterial efficacy against various bacterial strains.

A Desert Oasis of Innovation: Improving Antibacterial Therapy

This study, like a desert oasis, provides a refreshing approach to improving antibacterial therapy. The research's focus on developing a novel solid dispersion formulation for cefpodoxime proxetil offers a promising solution for enhanced drug delivery, increased solubility, and improved antibacterial efficacy.

A Path Through the Sands: Delivering Effective Antibacterial Treatment

This study provides a roadmap for navigating the challenges of drug delivery and achieving optimal antibacterial efficacy. The research highlights the importance of innovative formulation strategies to enhance solubility, improve drug absorption, and optimize treatment outcomes.

Dr.Camel's Conclusion

This study provides a valuable overview of the development of a novel lyophilized cefpodoxime proxetil solid dispersion formulation for enhanced antibacterial activity. The research demonstrates the importance of optimizing drug delivery to achieve improved solubility, reduced particle size, and enhanced wettability, leading to improved antibacterial efficacy and potentially more effective treatment outcomes.

Date :
  1. Date Completed 2021-11-01
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

33616480

DOI: Digital Object Identifier

10.1080/10837450.2021.1889584

Related Literature

Article Analysis
・Effects of cefpodoxime
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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