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Delivery routes matter: Safety and efficacy of intratumoral immunotherapy.

Author: De GeestBruno G, De LombaerdeEmily, De WeverOlivier

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Intratumoral immunotherapy offers a promising approach for cancer treatment by directly delivering immunostimulatory agents to the tumor site. This review discusses the current state of the art in preclinical and clinical intratumoral immunotherapy.
Paper Details　
Original Abstract of the Article :
Many anticancer immunotherapeutic agents, including the monoclonal immune checkpoint blocking antibodies, toll-like receptor (TLR) agonists, cytokines and immunostimulatory mRNA are commonly administrated by the intravenous route. Unfortunately, this route is prone to inducing, often life-threatenin...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbcan.2021.188526

データ提供：米国国立医学図書館（NLM）

Intratumoral Immunotherapy: A Targeted Approach to Cancer Treatment

[Intratumoral immunotherapy] is a promising new approach to cancer treatment that involves injecting [immunotherapeutic agents] directly into tumors. This study reviews the current state of the art in [intratumoral immunotherapy], exploring its potential benefits and challenges. The researchers discuss the advantages of intratumoral delivery of immunotherapeutic agents, including reduced systemic toxicity and improved efficacy.

A Targeted Approach to Cancer Treatment

This study sheds light on the promise of [intratumoral immunotherapy] as a targeted and effective approach to cancer treatment. By directly delivering [immunotherapeutic agents] to the tumor site, we can potentially overcome the challenges associated with systemic administration and achieve a more localized and potent response. It's like using a precise laser beam to target specific areas of the desert landscape, maximizing the effectiveness of our interventions.

A New Frontier in Cancer Research

The development of [intratumoral immunotherapy] represents a new frontier in cancer research, offering a more targeted and potentially safer approach to fighting this devastating disease. It's a testament to the ongoing quest for innovative and effective treatments, highlighting the potential for transforming the landscape of cancer care. Think of it as discovering a hidden oasis in the vast desert of cancer research, offering a new source of hope and healing.

Dr.Camel's Conclusion

This review highlights the potential benefits of [intratumoral immunotherapy], including reduced toxicity and improved efficacy, offering a new avenue for fighting cancer. It's a reminder that the desert of cancer research is constantly evolving, revealing new oases of hope and potential solutions for this challenging disease.

Date :
  1. Date Completed 2021-07-19
  2. Date Revised 2021-07-19
Further Info :

Pubmed ID

33617921

DOI: Digital Object Identifier

10.1016/j.bbcan.2021.188526

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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