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Dermal delivery and follicular targeting of adapalene using PAMAM dendrimers.

Author: BoranTuğçe, Emlik ÇalıkFiliz, GökçeBeyza B, GüngörSevgi, SanyalRana, ÖzhanGül

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study developed and optimized adapalene (ADA)-loaded PAMAM dendrimer-based nanocarriers for topical acne treatment. PAMAM dendrimers effectively delivered ADA to hair follicles, suggesting a potential approach for improving acne treatment efficacy.
Paper Details　
Original Abstract of the Article :
Acne is a chronic dermatological disease of pilosebaceous units existing in the form of hair follicles (HFs) and accompanying sebaceous glands. In topical acne treatment, localisation of drug substance at the target site, in pilosebaceous units, especially in HFs is essential. The aims of this study...See full text at original site
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引用元：
https://doi.org/10.1007/s13346-021-00933-6

データ提供：米国国立医学図書館（NLM）

Targeting Acne with PAMAM Dendrimers: A New Approach to Skin Care

Acne, a common skin condition, can be a frustrating and persistent problem. This research explores a novel approach to treating acne, using PAMAM dendrimers as drug delivery vehicles for adapalene, a widely used acne treatment. The authors designed and optimized adapalene-loaded PAMAM dendrimers for topical application.

PAMAM Dendrimers: A Targeted Approach to Acne Treatment

The study demonstrated that PAMAM dendrimers effectively deliver adapalene to the pilosebaceous units, the target site for acne treatment. These findings suggest that PAMAM dendrimers could be a promising new approach to treating acne, potentially leading to more effective and targeted therapy.

A Desert Oasis for Acne Sufferers

Imagine acne as a stubborn cactus in the desert of your skin, causing inflammation and discomfort. This research, like a camel seeking a hidden oasis, explores the potential of PAMAM dendrimers to effectively deliver treatment to the source of the problem, offering a path towards clearer skin and a more comfortable journey through the desert of acne.

Dr. Camel's Conclusion

Acne can be a stubborn desert dweller, causing blemishes and inflammation. This research, like a camel discovering a new route through the desert, presents PAMAM dendrimers as a potential solution for targeted acne treatment, offering a path towards clearer skin and a more confident outlook.

Date :
  1. Date Completed 2021-12-03
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

33666878

DOI: Digital Object Identifier

10.1007/s13346-021-00933-6

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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