Comparative Effects of Intragastric and Intraduodenal Administration of Quinine on the Plasma Glucose Response to a Mixed-Nutrient Drink in Healthy Men: Relations with Glucoregulatory Hormones and Gastric Emptying.

Author: BitarafanVida, Feinle-BissetChristine, FitzgeraldPenelope C E, HorowitzMichael, RezaiePeyman, RoseBraden D

Paper Details 
Original Abstract of the Article :
In preclinical studies, bitter compounds, including quinine, stimulate secretion of glucoregulatory hormones [e.g., glucagon-like peptide-1 (GLP-1)] and slow gastric emptying, both key determinants of postprandial glycemia. A greater density of bitter-taste receptors has been reported in the duodenu...See full text at original site
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引用元:
https://doi.org/10.1093/jn/nxab020

データ提供:米国国立医学図書館(NLM)

Intragastric vs. Intraduodenal Quinine Delivery

The digestive system is a complex and intricate desert, with diverse functions and sensitivities. This research investigates the impact of different delivery methods for quinine, a bitter compound, on blood glucose levels after a meal. The researchers compared intragastric and intraduodenal administration of quinine to determine its effects on glucose regulation and gastric emptying.

Delivery Matters: Navigating the Desert of Digestion

The researchers found that intraduodenal delivery of quinine was more effective in stimulating the release of glucoregulatory hormones and slowing gastric emptying. This research suggests that the location of drug delivery can significantly impact its effects on glucose regulation. It's like finding a more efficient path through the desert of digestion, leading to more effective and targeted therapeutic outcomes.

A New Path to Glucose Control: Oasis in the Desert of Digestion

This research highlights the importance of considering drug delivery methods in optimizing therapeutic effects. By understanding the nuances of drug delivery in the digestive system, researchers can develop more effective strategies for managing conditions like diabetes and obesity. It's like finding a new and efficient oasis in the desert of digestion, offering a path to better health and well-being.

Dr.Camel's Conclusion

This study highlights the importance of drug delivery methods in optimizing therapeutic outcomes, particularly in the context of glucose regulation. By understanding the impact of different delivery routes, researchers can develop more effective strategies for managing conditions like diabetes and obesity, creating a more efficient path through the desert of digestion.

Date :
  1. Date Completed 2022-01-10
  2. Date Revised 2023-02-16
Further Info :

Pubmed ID

33704459

DOI: Digital Object Identifier

10.1093/jn/nxab020

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Languages

English

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