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Adverse Effects of Oseltamivir Phosphate Therapy on the Liver of LDLR-/- Mice Without Any Benefit on Atherosclerosis and Thrombosis.

Author: BennasrouneAmar, BlaiseSébastien, BocquetOlivier, BoulagnonCamille, DucaLaurent, FougeratAnne, GayralStéphanie, GilleryPhilippe, HenryAubéri, JaissonStéphane, LaffargueMuriel, MartinyLaurent, MauricePascal, Romier-CrouzetBéatrice, SarazinThomas, SarteletHervé, SchneiderChristophe, VincentElise, WahartAmandine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Oseltamivir phosphate is a drug used to treat influenza. This study found that the drug may have limited benefits for atherosclerosis (hardening of the arteries) and may even cause liver problems.
Paper Details　
Original Abstract of the Article :
Desialylation, governed by sialidases or neuraminidases, is strongly implicated in a wide range of human disorders, and accumulative data show that inhibition of neuraminidases, such as neuraminidases 1 sialidase, may be useful for managing atherosclerosis. Several studies have reported promising ef...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/33760798

データ提供：米国国立医学図書館（NLM）

Oseltamivir Phosphate: Limited Benefits and Potential Liver Toxicity

This study explores the effects of oseltamivir phosphate, a commonly used antiviral medication for influenza, on atherosclerosis and thrombosis in mice. The researchers investigated the potential benefits and risks of oseltamivir phosphate in this context. The study found that while oseltamivir phosphate showed some beneficial effects on lipid levels and elastin fragmentation, it did not significantly impact atherosclerosis or thrombosis. Moreover, the study revealed that oseltamivir phosphate might have adverse effects on the liver, leading to increased inflammation and fibrosis. This research highlights the need for careful consideration of the potential risks and benefits of oseltamivir phosphate.

Oseltamivir Phosphate: Balancing Benefits and Risks

This study reveals a complex picture of oseltamivir phosphate's effects, suggesting that while it may have some beneficial effects, it also carries potential risks. The study findings highlight the importance of careful consideration of the potential benefits and risks of oseltamivir phosphate before prescribing it, especially in patients with pre-existing liver conditions. It's like navigating a desert where the oasis of benefit is often hidden behind a looming dune of potential toxicity.

Oseltamivir Phosphate: A Cautionary Tale

This study offers a cautionary tale about the potential risks and benefits of oseltamivir phosphate. The study findings highlight the importance of balancing potential benefits against the risk of adverse effects, especially on the liver. It's like a camel caravan venturing into a desert where the allure of a distant oasis may not always outweigh the risks of a treacherous journey.

Dr.Camel's Conclusion

This study underscores the need for careful consideration of the potential benefits and risks of oseltamivir phosphate, particularly in patients with pre-existing liver conditions. It reminds us that even seemingly safe medications can have unexpected side effects, emphasizing the importance of a comprehensive approach to patient care.

Date :
  1. Date Completed 2021-12-08
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

33760798

DOI: Digital Object Identifier

00005344-202105000-00016

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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