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Pharmacological Treatment of Osteoporosis in Elderly People: A Systematic Review and Meta-Analysis.

Author: ChenRong, DingNa, DongYi-He, LiuHong, LiuShu-Ying, OuYang-Na, ShengZhi-Feng, WangQin-Yi, WenZhang-Xin

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Antiresorptive and anabolic agents were effective in reducing vertebral, nonvertebral, and hip fracture risk in elderly patients with osteoporosis. These agents were also well tolerated.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The evidence supporting the use of antiresorptive and anabolic agents for fracture prevention in elderly patients is still inconclusive. Whether it is too late to alter the course of the disease in this age-group has remained uncertain. OBJECTIVES: The objective of this study was to det...See full text at original site
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引用元：
https://doi.org/10.1159/000514449

データ提供：米国国立医学図書館（NLM）

Pharmacological Treatment of Osteoporosis in Elderly People: A Systematic Review and Meta-Analysis

Osteoporosis, a condition characterized by weakened bones, is a significant concern for older adults. This research examines the efficacy and safety of antiresorptive and anabolic agents in preventing fractures in elderly patients. The authors conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and post hoc analyses of RCTs, concluding that both antiresorptive and anabolic agents represent potentially important osteoporosis treatments, showing significant effects on reducing vertebral, nonvertebral, or hip fracture risk, and were well-tolerated by elderly patients.

Treating Osteoporosis in the Elderly: A Focus on Fracture Prevention

The study's findings provide evidence for the effectiveness of antiresorptive and anabolic agents in reducing the risk of fractures in elderly patients with osteoporosis. The meta-analysis of 12 studies demonstrated significant reductions in the incidence of vertebral, nonvertebral, and hip fractures in patients treated with these agents compared to those receiving placebo. This research underscores the importance of pharmacological interventions for osteoporosis prevention in the elderly.

Maintaining Bone Health in Later Life: A Lifelong Journey

Maintaining bone health throughout life is crucial for preventing osteoporosis and fractures, particularly in later life. This research highlights the importance of early intervention and the potential benefits of pharmacological treatments like antiresorptive and anabolic agents in managing osteoporosis in the elderly. The findings emphasize the need for a comprehensive approach to bone health, incorporating lifestyle modifications, nutrition, and appropriate medical management.

Dr. Camel's Conclusion

Just as a camel's hump provides a reserve of energy for long journeys, strong bones are essential for maintaining mobility and independence in later life. This research, like a well-worn desert path, guides us towards better understanding and treating osteoporosis in the elderly, helping them to navigate the challenges of aging with greater strength and resilience.

Date :
  1. Date Completed 2022-02-28
  2. Date Revised 2022-02-28
Further Info :

Pubmed ID

33823511

DOI: Digital Object Identifier

10.1159/000514449

Related Literature

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・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

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