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Effect of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Women: A Randomized Clinical Trial.

Author: FongWilliam Pat, HuMing-Tao, JinYing, LiYu-Hong, LuoHui-Yan, PengJie-Wen, QiuMiao-Zhen, RenChao, TanQiong, WangDe-Shen, WangFeng-Hua, WangShu-Bin, WangZhi-Qiang, ZouQing-Feng

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A phase 3, double-blind, placebo-controlled randomized clinical trial of 248 women with gastrointestinal cancer found that the combination of aprepitant with palonosetron and dexamethasone provided increased antiemetic efficacy in the FOLFOX or FOLFIRI chemotherapy regimen and was well tolerated. The complete response (CR) rate was significantly higher in the aprepitant group than in the control group (87.0% vs 66.7%).
Paper Details　
Original Abstract of the Article :
IMPORTANCE: The prevention of chemotherapy-induced nausea and vomiting has an important role in the overall management of cancer treatment. OBJECTIVE: To evaluate whether adding aprepitant to palonosetron and dexamethasone can further prevent the incidence and severity of nausea and vomiting caused...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035650/

データ提供：米国国立医学図書館（NLM）

Preventing Nausea and Vomiting in Cancer Treatment

Navigating the challenging landscape of cancer treatment often involves a grueling trek through side effects, such as nausea and vomiting. This study, akin to a camel caravan carefully traversing a treacherous sandstorm, sought to mitigate these side effects by exploring the efficacy of aprepitant, a medication known for its anti-nausea properties.

Aprepitant: A Potential Oasis in the Desert of Nausea

This study found that aprepitant, when combined with other anti-nausea medications, significantly reduced both the incidence and severity of nausea and vomiting in women with gastrointestinal cancer undergoing chemotherapy. The study's findings suggest that aprepitant can be a valuable tool for improving the quality of life for patients undergoing these difficult treatments.

Navigating the Side Effects

While aprepitant demonstrated significant benefits in reducing nausea and vomiting, it's important to note that the study also found that aprepitant was well-tolerated by patients. This is akin to finding a refreshing oasis amidst a scorching desert. These findings provide a glimmer of hope for patients who have previously struggled with the debilitating side effects of chemotherapy.

Dr. Camel's Conclusion

This study offers a beacon of hope in the challenging terrain of cancer treatment. The addition of aprepitant to the existing anti-nausea regimen appears to provide a significant oasis of relief for patients, allowing them to better cope with the side effects of chemotherapy. This research underscores the importance of continuing to explore new ways to improve the quality of life for cancer patients, making their journey through treatment a bit less arduous.

Date :
  1. Date Completed 2021-08-19
  2. Date Revised 2021-08-19
Further Info :

Pubmed ID

33835174

DOI: Digital Object Identifier

PMC8035650

Related Literature

Article Analysis
・Effective treatment of nausea
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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