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Linaclotide for the treatment of refractory lower bowel manifestations of systemic sclerosis.

Author: DeinEric J, McMahanZsuzsanna H, WigleyFredrick M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study reports on the use of linaclotide, a selective agonist of guanylate cyclase C (GC-C), in patients with systemic sclerosis (SSc) and refractory lower gastrointestinal disease. Linaclotide showed promising results in improving symptoms and reducing the need for hospitalization.
Paper Details　
Original Abstract of the Article :
Lower gastrointestinal (GI) tract involvement can affect up to 50% of systemic sclerosis (SSc) patients, and may result in malabsorption, pseudo-obstruction, hospitalization, and death. We report our experience with linaclotide, a selective agonist of guanylate cyclase C (GC-C), for SSc patients wit...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051106/

データ提供：米国国立医学図書館（NLM）

Linaclotide: A Hopeful Oasis in the Desert of SSc

This study explores the potential of linaclotide, a selective agonist of guanylate cyclase C (GC-C), for the treatment of refractory lower gastrointestinal (GI) disease in patients with systemic sclerosis (SSc), a condition that can leave individuals feeling lost in a desert of symptoms and challenges.

Finding Relief: Linaclotide's Promise

The study reports on the experiences of patients with SSc and refractory lower GI disease who were treated with linaclotide, finding encouraging results in their journey to find relief. It's like discovering a hidden oasis in the desert, offering a much-needed source of comfort and improvement.

Living with SSc: A Journey of Resilience

This study highlights the importance of finding effective treatments for SSc and its associated complications. It's like a camel adapting to the harsh conditions of the desert, finding ways to survive and thrive. By exploring new treatment options and collaborating with healthcare professionals, individuals can manage their SSc and live a more fulfilling life.

Dr.Camel's Conclusion

This study offers a beacon of hope for patients battling SSc and its associated complications. The promising results of linaclotide suggest a potential new avenue for treatment, providing a lifeline in the desert of this challenging condition. It's a journey of perseverance, where we continue to seek solutions and embrace the potential for healing and improvement.
Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

33858329

DOI: Digital Object Identifier

PMC8051106

Related Literature

Article Analysis
・Side Effects of linaclotide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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