Vortioxetine Derivatives with Amino Acid as Promoiety: Synthesis, Activity, Stability and Preliminary Pharmacokinetic Study.

Author: BiXinzhou, LiJing, LiXiaolei, LiYuanyuan, MoXianwei, ZhouHaiyan, ZhuXinying

Paper Details 
Original Abstract of the Article :
Vortioxetine (Vot) is an effective antidepressant with unique mechanisms exerting multi-target effects. However, severe side-effects such as nausea and vomiting are commonly experienced under conditions of long-term administration. Eight amino acid modified Vot derivatives were designed and prepared...See full text at original site
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引用元:
https://doi.org/10.1016/j.xphs.2021.04.011

データ提供:米国国立医学図書館(NLM)

Vortioxetine: A New Oasis in the Desert of Depression

The quest for effective and safe treatments for depression is a journey through a vast and sometimes treacherous desert. This study explores the potential of modifying vortioxetine, a promising antidepressant, to improve its efficacy and safety profile. The researchers synthesized and evaluated eight amino acid-modified derivatives of vortioxetine, seeking to enhance its therapeutic properties while reducing its adverse effects. Their findings suggest that modifying vortioxetine with specific amino acids, such as threonine and serine, can potentially improve its pharmacokinetic properties, leading to a more favorable therapeutic profile. This discovery is like finding a hidden spring of clear water in the desert, offering a potential source of relief and healing.

Vortioxetine Derivatives: A New Frontier in Antidepressant Treatment

This research offers a glimpse into the future of antidepressant treatment, showcasing the potential of modifying existing medications to create safer and more effective therapies. The study's findings suggest that amino acid-modified derivatives of vortioxetine may offer a more favorable balance between efficacy and safety, providing a potential solution to some of the challenges associated with conventional antidepressant therapy. This discovery could lead to a new era of personalized medicine, tailored to the unique needs of each patient.

Navigating Depression Treatment: A Guide for Patients

The treatment of depression can be a challenging journey, but it's essential to remember that there are options available. Open communication with your healthcare provider is crucial for ensuring that you receive the most appropriate treatment for your individual needs. It's like having a skilled guide to navigate the complexities of depression treatment, helping you find your way through the desert and towards a brighter future. Don't be afraid to seek help and explore all available options to manage your symptoms and improve your quality of life.

Dr.Camel's Conclusion

This study provides a fascinating glimpse into the potential of modifying existing medications to enhance their efficacy and safety. It's like finding a new oasis in the vast desert of depression treatment, offering a potential source of hope for patients seeking a more effective and personalized approach to managing their condition. This research is a testament to the relentless pursuit of new solutions in the fight against depression, a condition that affects millions worldwide.

Date :
  1. Date Completed 2021-08-04
  2. Date Revised 2021-08-04
Further Info :

Pubmed ID

33891948

DOI: Digital Object Identifier

10.1016/j.xphs.2021.04.011

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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