Paper Details

  1. Home
  2. Paper Details

Selection of the optimal dosage of tranexamic acid to reduce blood loss during pediatric cleft palate surgery.

Author: Adineh-MehrLili, BahramiKeivan, ShafaAmir, ShetabiHamidreza

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tranexamic acid (TXA) was evaluated for its effectiveness in reducing blood loss during cleft palate surgery in 80 children under 3 years of age. The study found that all three dosages of TXA (5, 7.5, and 10 mg/kg) significantly reduced blood loss compared to the control group. The minimal dosage (5 mg/kg) is recommended to minimize the risk of side effects.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The aim of the present study was to evaluate and select the optimal dosage of tranexamic acid (TXA) to reduce blood loss during cleft palate surgery in children. MATERIALS AND METHODS: This randomized double-blind clinical trial was performed on 80 children under 3 years of age that were...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059463/

データ提供：米国国立医学図書館（NLM）

Finding the Right Dose of Tranexamic Acid for Pediatric Cleft Palate Surgery: A Balancing Act

The world of [Cleft palate surgery] is a delicate landscape, and this study explores the use of [Tranexamic acid (TXA)] to reduce blood loss during this procedure in children. The researchers investigated the optimal dosage of [TXA] to achieve the desired effect without increasing the risk of side effects.

TXA Effective in Reducing Blood Loss During Cleft Palate Surgery

The study found that all three doses of [TXA] (5, 7.5, and 10 mg/kg) significantly reduced blood loss during [Cleft palate surgery]. This finding suggests that [TXA] can be a valuable tool for managing blood loss during this procedure, potentially leading to better outcomes for patients.

Choosing the Right Dose for Optimal Safety and Effectiveness

The study emphasizes the importance of choosing the appropriate dosage of [TXA] to achieve the best balance between effectiveness and safety. While higher doses were effective in reducing blood loss, they also carried a slightly increased risk of side effects. The researchers recommend using the lowest effective dose to minimize potential risks.

Dr.Camel's Conclusion

This study provides valuable insights into the use of [TXA] during [Cleft palate surgery]. The findings suggest that [TXA] can be a valuable tool for managing blood loss, but careful dose selection is crucial to optimize safety and effectiveness. Continued research is essential to further refine the use of [TXA] in this specific context, ensuring the best possible outcomes for pediatric patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-22
Further Info :

Pubmed ID

33912417

DOI: Digital Object Identifier

PMC8059463

Related Literature

Article Analysis
・Side Effects of tranexamic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.