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Cephradine and flucloxacillin in the prophylaxis of infection in patients with open fractures.

Author: AlparE K

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cephradine was more effective than flucloxacillin in preventing infections in patients with open fractures, with flucloxacillin also being associated with more gastrointestinal side effects.
Paper Details　
Original Abstract of the Article :
A comparison of prophylactic antibiotic cover of cephradine or flucloxacillin in sixty patients with open fractures is reported. There were more infections in the flucloxacillin than in the cephradine group and gastrointestinal side-effects were more common. The overall incidence of infection in the...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2710.1988.tb00166.x

データ提供：米国国立医学図書館（NLM）

Preventing Infections in Open Fractures: A Comparative Study of Antibiotics

Open fractures, where the broken bone penetrates the skin, are a serious injury prone to infection. This research investigates the effectiveness of two antibiotics, cephradine and flucloxacillin, in preventing infection in patients with open fractures. The authors compared the outcomes of 60 patients who received either cephradine or flucloxacillin as prophylactic treatment, analyzing the incidence of infections and gastrointestinal side effects.

The Power of Prevention: A Closer Look at Antibiotic Efficacy

The study found a lower incidence of infections in the cephradine group compared to the flucloxacillin group. While the overall incidence of infection was relatively low, the findings highlight the importance of choosing the right antibiotic for prophylactic treatment. The authors also noted a higher prevalence of gastrointestinal side effects in the flucloxacillin group, suggesting the potential for different medications to have distinct side effect profiles.

Making the Right Choice: Navigating Antibiotic Therapy

This research underscores the critical role of appropriate antibiotic selection in preventing infections associated with open fractures. While both cephradine and flucloxacillin showed effectiveness in reducing infection rates, cephradine emerged as a potentially superior choice, with a lower risk of side effects. Patients with open fractures should consult with their doctors to choose the most suitable antibiotic based on their individual needs and circumstances.

Dr. Camel's Conclusion

Imagine an open fracture as a crack in the desert's protective crust, exposing the vulnerable terrain to the scorching sun and infiltrating sandstorms. Cephradine and flucloxacillin, like two different oases, offer a haven from infection. This research, like a camel caravan navigating the diverse landscapes of the desert, reveals the importance of choosing the right oasis for the specific needs of the journey.

Date :
  1. Date Completed 1988-08-24
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

3392125

DOI: Digital Object Identifier

10.1111/j.1365-2710.1988.tb00166.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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