The 5-HT<sub>3</sub> Receptor Affects Rotavirus-Induced Motility.

Author: HagbomMarie, HellysazArash, IstrateClaudia, MagnussonKarl-Eric, NordgrenJohan, SharmaSumit, SvenssonLennart, de-FariaFelipe Meira

Paper Details 
Original Abstract of the Article :
Rotavirus infection is highly prevalent in children, and the most severe effects are diarrhea and vomiting. It is well accepted that the enteric nervous system (ENS) is activated and plays an important role, but knowledge of how rotavirus activates nerves within ENS and to the vomiting center is lac...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274622/

データ提供:米国国立医学図書館(NLM)

Rotavirus: A Microbial Master of Gut Manipulation

Rotavirus, a common cause of diarrhea and vomiting in children, has long been a thorn in the side of researchers. This study delves into the complex interplay between rotavirus and the enteric nervous system (ENS), exploring how this virus hijacks the nervous system to cause its characteristic symptoms. The researchers used a mouse model to investigate the role of the 5-HT3 receptor, a key player in the signaling pathways within the ENS, in rotavirus-induced illness.

A New Target for Treating Rotavirus Diarrhea

The study provides intriguing evidence that the 5-HT3 receptor plays a significant role in rotavirus-induced diarrhea. Mice lacking this receptor exhibited less severe diarrhea and reduced intestinal motility. This suggests that the 5-HT3 receptor acts as a conductor, orchestrating the muscle contractions that drive the flow of food and waste through the intestines. By disrupting this signaling pathway, the researchers were able to reduce the severity of rotavirus-induced diarrhea.

A Potential New Approach for Rotavirus Treatment

These findings open a new door for treating rotavirus diarrhea. Targeting the 5-HT3 receptor could potentially provide a novel therapeutic strategy to combat the debilitating effects of this virus. It's like having a map that reveals the hidden pathways by which rotavirus manipulates the body, allowing us to create more effective interventions.

Dr. Camel's Conclusion

Rotavirus, a cunning desert nomad, has long outwitted researchers. But this study offers a glimmer of hope, suggesting that understanding the virus's tactics can help us create new weapons to combat its assault. Targeting the 5-HT3 receptor could be a game changer in the fight against rotavirus diarrhea, potentially providing much-needed relief for children suffering from this common and often debilitating illness.

Date :
  1. Date Completed 2021-08-25
  2. Date Revised 2022-01-13
Further Info :

Pubmed ID

33980599

DOI: Digital Object Identifier

PMC8274622

Related Literature

SNS
PICO Info
in preparation
Languages

English

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