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Immunogenicity and safety of two monovalent rotavirus vaccines, ROTAVAC® and ROTAVAC 5D® in Zambian infants.

Author: BabjiS, BhatN, ChilengiR, ChipetaC, ChirwaM, FloresJ, GompanaG, HazraS, KangG, KatanekwaN, McNealM M, MeyerN, Mwila-KazimbayaK, RathiN, SukwaN, TangY, VeluR M

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the safety and immunogenicity of two rotavirus vaccines, ROTAVAC and ROTAVAC 5D, in infants in Zambia. Both vaccines were derived from the same strain and showed similar safety profiles, but ROTAVAC 5D is more stable and easier to store.
Paper Details　
Original Abstract of the Article :
ROTAVAC® (frozen formulation stored at -20 °C) and ROTAVAC 5D® (liquid formulation stable at 2-8 °C) are rotavirus vaccines derived from the 116E human neonatal rotavirus strain, developed and licensed in India. This study evaluated and compared the safety and immunogenicity of these vaccines in an ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204902/

データ提供：米国国立医学図書館（NLM）

Protecting Infants from Rotavirus: A Comparison of Two Vaccines

Rotavirus, like a relentless desert storm, can cause severe diarrhea and dehydration, especially in infants. This research investigates the safety and effectiveness of two different rotavirus vaccines, ROTAVAC® and ROTAVAC 5D®, in infants in Zambia.

The researchers conducted a clinical trial, comparing the immunogenicity (ability to trigger an immune response) and safety of these two vaccines in a group of infants. They aimed to determine if these vaccines effectively protect against rotavirus infection while ensuring their safety.

Their findings suggest that both vaccines are safe and effective in inducing an immune response against rotavirus infection. This provides valuable information for healthcare providers in selecting the most appropriate vaccine for infants in Zambia.

Protecting Our Youngest: A Step Towards a Healthier Future

The study highlights the importance of vaccination in protecting infants from serious infections. The availability of safe and effective rotavirus vaccines is a significant step towards reducing the burden of this disease and ensuring a healthier future for children.

A Call for Global Health Equity: Expanding Access to Vaccines

The study underscores the importance of ensuring equitable access to vaccines worldwide. Efforts to expand vaccination programs, particularly in regions where rotavirus infection is prevalent, are crucial for protecting children and improving global health outcomes.

Dr. Camel's Conclusion

This study, like a protective oasis in the vast desert of childhood diseases, offers a beacon of hope for infants in Zambia. The findings demonstrate the efficacy and safety of two rotavirus vaccines, paving the way for a healthier future for children.

Date :
  1. Date Completed 2021-07-08
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

33992437

DOI: Digital Object Identifier

PMC8204902

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SNS
PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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