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Drug-induced liver injury in Switzerland: an analysis of drug-related hepatic disorders in the WHO pharmacovigilance database VigiBase from 2010 to 2020.

Author: Kullak-UblickGerd A, MirjaliliMahtabalsadat, OrtlandImke, PeymaniPayam

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated drug-induced liver injury in Switzerland using the global pharmacovigilance database VigiBase, focusing on checkpoint inhibitors.
Paper Details　
Original Abstract of the Article :
Our aim was to explore drug-induced liver injury (DILI) in Switzerland using the real-world data of the global pharmacovigilance database VigiBaseÔ, with a special focus on the new drug class of checkpoint inhibitors. This is the first study investigating drug-related hepatic disorders in Swit...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34000058

データ提供：米国国立医学図書館（NLM）

Drug-Induced Liver Injury: A Global Perspective

Drug-induced liver injury (DILI) is a serious concern, impacting individuals worldwide. This study examines the prevalence of DILI in Switzerland, analyzing data from the [WHO pharmacovigilance database VigiBase]. The study focuses on [checkpoint inhibitors], a new class of drugs used in cancer treatment, and explores their potential role in DILI. The analysis provides valuable insights into the global occurrence of DILI, highlighting the importance of pharmacovigilance and patient safety.

DILI: A Global Health Concern

This study underscores the global nature of DILI and the need for continued monitoring of drug safety. The analysis provides valuable information about the occurrence of DILI in Switzerland and highlights the importance of considering the potential for DILI when prescribing new medications.

Understanding and Managing DILI

Understanding the risk factors and potential causes of DILI is crucial for healthcare professionals. This study provides valuable data that can help clinicians make informed decisions regarding drug selection and monitoring, ensuring patient safety.

Dr.Camel's Conclusion

Just as a camel needs to be wary of poisonous plants in the desert, healthcare professionals must remain vigilant about the potential for drug-induced liver injury. This study provides a valuable roadmap for navigating the vast landscape of DILI, promoting patient safety and advancing our understanding of drug-related liver complications.

Date :
  1. Date Completed 2021-10-19
  2. Date Revised 2021-10-19
Further Info :

Pubmed ID

34000058

DOI: Digital Object Identifier

Swiss Med Wkly. 2021;151:w20503

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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