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Combination antiretroviral therapy improves recurrent primary biliary cholangitis following liver transplantation.

Author: HeDaniel, HübscherStefan G, LytvyakEllina, MasonAndrew L, NiaziMina, PaiRohit, ZhangGuangzhi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Combination antiretroviral therapy, specifically tenofovir/emtricitabine-based regimens with lopinavir or raltegravir, was used to manage recurrent primary biliary cholangitis in two patients. It resulted in sustained biochemical and histological improvement but was associated with side effects.
Paper Details　
Original Abstract of the Article :
Recurrent primary biliary cholangitis (rPBC) is frequent following liver transplantation and associated with increased morbidity and mortality. It has been argued that rPBC behaves like an infectious disease because more potent immunosuppression with tacrolimus is associated with earlier and more se...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362166/

データ提供：米国国立医学図書館（NLM）

Recurrent Primary Biliary Cholangitis: A Sandstorm After Transplantation

Primary biliary cholangitis (PBC) is a chronic liver disease that can be like a persistent sandstorm in the body, affecting the delicate balance of liver function. This research explores the potential benefits of combination antiretroviral therapy (ART) for managing recurrent PBC (rPBC) following liver transplantation.

The researchers found that combination ART can significantly improve hepatic biochemistry in patients with rPBC. However, they also acknowledged the potential side effects associated with ART. This research adds to the growing body of evidence suggesting that PBC may be caused by a human betaretrovirus. It's like exploring a new theory in the desert of liver disease - the researchers are trying to understand if a specific virus is causing the sandstorm.

Navigating the Liver's Desert

This research offers a potential new treatment approach for rPBC, but emphasizes the need for careful monitoring and management. The researchers are like desert explorers, seeking out new and innovative ways to manage this challenging liver disease.

Liver Health: A Vital Oasis

This research highlights the importance of early detection and treatment of liver diseases. Maintaining a healthy lifestyle and seeking medical advice at the first sign of liver problems are essential for protecting this vital organ.

Dr.Camel's Conclusion

This research delves into the complex world of liver disease, uncovering potential links between PBC and retroviruses. The exploration of ART as a treatment option for rPBC is a promising development in the field of liver transplantation. It's like finding a new oasis in the desert of liver health, offering hope for patients with this challenging condition.

Date :
  1. Date Completed 2021-08-02
  2. Date Revised 2021-08-18
Further Info :

Pubmed ID

34008271

DOI: Digital Object Identifier

PMC8362166

SNS
PICO Info
in preparation
Languages

English

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