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Outcomes after breast-conserving surgery or mastectomy in patients with triple-negative breast cancer: meta-analysis.

Author: FancelluA, HoussamiN, MarinovichM L, NinniriC, PorcuA, SannaV

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis of 14 studies involving 19,819 patients with triple-negative breast cancer found that breast-conserving surgery (BCS) was not associated with a worse prognosis compared to mastectomy. While BCS showed a statistically significant lower odds of locoregional recurrence (0.64) and a lower odds of distant metastasis (0.70), the difference in DM diminished with increasing age and follow-up time. Overall, BCS was associated with a significantly lower hazard for all-cause mortality (0.78).
Paper Details　
Original Abstract of the Article :
BACKGROUND: In patients with triple-negative breast cancer (TNBC), oncological and survival outcomes based on locoregional treatment are poorly understood. In particular, the safety of breast-conserving surgery (BCS) for TNBC has been questioned. METHODS: A meta-analysis was performed to evaluate l...See full text at original site
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引用元：
https://doi.org/10.1093/bjs/znab145

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Triple-Negative Breast Cancer: Exploring the Safety and Efficacy of Breast-Conserving Surgery

In the vast and often challenging landscape of breast cancer, we seek effective and safe treatments for our patients. This meta-analysis explores the safety and efficacy of breast-conserving surgery (BCS) versus mastectomy in patients with triple-negative breast cancer (TNBC), a particularly aggressive form of the disease. It's like navigating a challenging desert terrain, carefully considering the best path to navigate the complexities of this disease.

A New Path in the Desert: Breast-Conserving Surgery Shows Promise for TNBC

This meta-analysis offers a promising new path in the desert of TNBC treatment. The study found that BCS, when feasible, does not appear to compromise oncological outcomes or survival rates compared to mastectomy. This finding is like discovering a hidden oasis in the desert, offering a new and potentially less invasive treatment option for patients with TNBC. While further research is needed, the study suggests that BCS may be a viable and safe option for carefully selected patients with TNBC.

Finding the Oasis of Hope: Balancing Safety and Efficacy in TNBC Treatment

This meta-analysis emphasizes the importance of finding a balance between safety and efficacy in TNBC treatment. The study suggests that BCS can be a safe and effective option for select patients, offering a less invasive approach to breast cancer treatment. It's like finding a hidden oasis in the desert, a place of healing and hope for those facing the challenges of TNBC. By carefully considering individual patient factors and utilizing evidence-based guidelines, clinicians can help patients navigate the challenging terrain of TNBC treatment with confidence and hope.

Dr. Camel's Conclusion

This meta-analysis is a valuable step in the ongoing journey to find effective and safe treatments for TNBC. It's like discovering a new path in the desert, offering a potential oasis of hope for patients with this aggressive form of breast cancer. While further research is needed, the study suggests that BCS may be a viable and safe option for carefully selected patients with TNBC, offering a less invasive approach to treatment and potentially enhancing quality of life.

Date :
  1. Date Completed 2021-10-05
  2. Date Revised 2022-02-22
Further Info :

Pubmed ID

34057990

DOI: Digital Object Identifier

10.1093/bjs/znab145

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・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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