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Short-term glucocorticoid excess blunts abaloparatide-induced increase in femoral bone mass and strength in mice.

Author: BrentMikkel Bo, BrüelAnnemarie, ThomsenJesper Skovhus

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Glucocorticoids (GCs), like prednisolone, are effective for treating inflammation, but long-term use can lead to bone loss. This study investigated how GCs affect the bone-building effects of a drug called abaloparatide. The researchers found that while abaloparatide improved bone density in mice, the beneficial effects were reduced when GCs were also given. This suggests that GCs can hinder the positive effects of abaloparatide on bone strength.
Paper Details　
Original Abstract of the Article :
Glucocorticoids (GCs), such as prednisolone, are widely used to treat inflammatory diseases. Continuously long-term or high dose treatment with GCs is one of the most common causes of secondary osteoporosis and is associated with sarcopenia and increased risk of debilitating osteoporotic fragility f...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192916/

データ提供：米国国立医学図書館（NLM）

Glucocorticoids and Bone Health: A Balancing Act

This research investigates the complex interplay between glucocorticoids (GCs), commonly used medications for inflammatory conditions, and the osteoanabolic effects of abaloparatide, a bone-building drug. The study, conducted on mice, explored the impact of short-term GC excess on bone mass and strength, finding that GC excess can blunt the bone-building effects of abaloparatide.

GCs: A Double-Edged Sword

The study reveals the potential of GCs to interfere with bone-building processes, suggesting that careful consideration of bone health is necessary when using these medications.

Navigating the Shifting Sands of Bone Health

This research reminds us that maintaining strong bones is a delicate balance, influenced by various factors, including medications. It highlights the importance of discussing potential risks and benefits of medications with healthcare professionals, especially those that might impact bone health.

Dr.Camel's Conclusion

This study serves as a reminder that while medications can provide much-needed relief, they may also have unintended consequences. It emphasizes the importance of a holistic approach to health, considering the potential impact of medications on different organ systems. Just as a desert traveler must carefully plan their journey, we must be mindful of the potential effects of medications on our bodies. Open communication with healthcare professionals is crucial for making informed decisions about our health and ensuring a safe and healthy journey through life's challenges.

Date :
  1. Date Completed 2021-10-27
  2. Date Revised 2021-10-27
Further Info :

Pubmed ID

34112892

DOI: Digital Object Identifier

PMC8192916

Related Literature

Article Analysis
・Effects of abaloparatide injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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