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Reductions in tobacco use in naltrexone, relative to buprenorphine-maintained individuals with opioid use disorder: Secondary analysis from the National Drug Abuse Treatment Clinical Trials Network.

Author: CampbellAimee N C, MontgomeryLaTrice, NunesEdward V, PavlicovaMartina, RotrosenJohn, ScodesJennifer, TwittyDylanne, WangAn Li, WinhusenTheresa

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study explores the relationship between opioid use and smoking cessation in people with opioid use disorder (OUD). The study suggests that opioid use may make it harder to quit smoking, even with standard treatments. The researchers aim to determine if a medication that blocks the effects of opioids (XR-NTX) leads to better smoking outcomes compared to another medication that partially activates opioid receptors (BUP-NX).
Paper Details　
Original Abstract of the Article :
Smoking prevalence in individuals with opioid use disorder (OUD) is over 80%. Research suggests that opioid use significantly increases smoking, which could account for the strikingly low smoking-cessation rates observed in both methadone- and buprenorphine-maintained patients, even with the use of ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34118716

データ提供：米国国立医学図書館（NLM）

Naltrexone and Tobacco Use in Opioid Use Disorder

This study investigates the relationship between opioid use disorder (OUD) and tobacco use, a significant public health challenge. The researchers analyzed data from a clinical trial network, focusing on individuals receiving treatment for OUD with either naltrexone or buprenorphine. Their findings reveal that patients receiving naltrexone, an opioid antagonist, exhibited a greater reduction in tobacco use compared to those receiving buprenorphine, a partial opioid agonist. The study underscores the potential role of opioid antagonism in facilitating smoking cessation in individuals with OUD.

Opioid Antagonism: A Potential Aid in Smoking Cessation

This study is like a compass guiding us through the complexities of OUD and tobacco use. The findings suggest that blocking the effects of opioids may play a critical role in helping individuals with OUD quit smoking. This discovery offers a potential avenue for improving the health outcomes of individuals with OUD, a population disproportionately affected by smoking-related health problems.

Breaking the Chains of Addiction

The struggle with opioid use disorder and tobacco use is a challenging one. However, this study offers hope that blocking the effects of opioids could be a key to helping individuals break the cycle of addiction and improve their overall health. It's essential to seek professional help and explore all available treatment options, just as a camel seeks a safe passage through the desert.

Dr.Camel's Conclusion

This study is a beacon of hope in the desert of addiction. The findings suggest that naltrexone, by blocking the effects of opioids, may offer a valuable tool for helping individuals with OUD quit smoking. While more research is needed, this study offers a promising avenue for improving the lives of those grappling with these challenging conditions.

Date :
  1. Date Completed 2021-11-02
  2. Date Revised 2021-11-02
Further Info :

Pubmed ID

34118716

DOI: Digital Object Identifier

NIHMS1710533

Related Literature

Article Analysis
・Effective treatment of opioid use
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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