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Effect of Age on Clinical Trial Outcome in Participants with Probable Alzheimer's Disease.

Author: AsaadWael F, BurkeAnna D, DrakeKristen E, FooteKelly D, FosdickLisa, LozanoAndres M, LyketsosConstantine G, RosenbergPaul B, SabbaghMarwan, SmithGwenn S, TargumSteven D, WolkDavid A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Age may be a significant factor affecting treatment outcome in trials for Alzheimer's disease. Younger participants may experience faster disease progression and different AD subtypes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Age may affect treatment outcome in trials of mild probable Alzheimer's disease (AD). OBJECTIVE: We examined age as a moderator of outcome in an exploratory study of deep brain stimulation targeting the fornix (DBS-f) region in participants with AD. METHODS: Forty-two participants were...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461716/

データ提供：米国国立医学図書館（NLM）

Age and Alzheimer's Disease: Navigating the Shifting Sands of Treatment

This research investigates the potential impact of age on treatment outcomes for individuals with probable Alzheimer's disease (AD). The study, like a camel caravan traversing a challenging landscape, explores the complexities of AD and the potential differences in response to treatment based on age. Researchers sought to understand if age influences the effectiveness of deep brain stimulation targeting the fornix (DBS-f) region, a promising but still experimental treatment for AD.

The Shifting Sands of Age and Alzheimer's

The study found that while DBS-f was safe and well-tolerated, the chosen clinical measures did not show significant differences between the stimulated and sham groups in the overall population. However, a significant interaction between age and time was observed, suggesting that younger participants with AD may experience a faster disease progression compared to older participants.

Tailoring Treatment for a Complex Desert

This research highlights the importance of considering age as a factor when evaluating treatment options for AD. It emphasizes the need for careful patient selection and further research to understand the complexities of AD and its response to treatment across different age groups.

Dr.Camel's Conclusion

This study sheds light on the intricate relationship between age and Alzheimer's disease, much like a camel navigating a desert where the terrain constantly shifts. It underscores the importance of tailored treatment approaches and further research to understand the complexities of this disease and its response to therapy across different age groups.

Date :
  1. Date Completed 2021-09-15
  2. Date Revised 2021-11-19
Further Info :

Pubmed ID

34151817

DOI: Digital Object Identifier

PMC8461716

Related Literature

Article Analysis
・Effective treatment of alzheimer's disease
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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