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Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review.

Author: Borić BilušićAna, BožinaNada, BožinaTamara, DomjanovićIva Klarica, Fistrek PrlićMargareta, GanociLana, GvozdanovićKatarina, KrižTena, LaganovićMario, SimičevićLivija

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This case report highlights the potential for drug-drug-gene interactions to cause adverse drug reactions (ADRs) in a patient treated with multiple medications, including statins and NSAIDs. The case demonstrates the importance of pharmacogenomic analysis in personalized medicine, as it can help predict and prevent ADRs.
Paper Details　
Original Abstract of the Article :
Concomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with prolonged drug exposure and increased risk of adverse drug reactions (ADRs) due to drug-drug in...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265195/

データ提供：米国国立医学図書館（NLM）

Drug-Drug-Gene Interactions: A Complex Landscape of Adverse Drug Reactions

Concomitant drug use can lead to drug-drug interactions, potentially increasing the risk of adverse drug reactions (ADRs). This study explores a case report of a 46-year-old woman who experienced acute renal and hepatic injury and myalgia after taking several medications, including diclofenac, atorvastatin, simvastatin/fenofibrate, pantoprazole, and furosemide. The authors investigated potential drug-drug-gene interactions and their role in mediating the patient's ADRs. They analyzed the patient's pharmacogenomic profile, looking for genetic variations that could influence drug metabolism and disposition.

Pharmacogenomics: A Personalized Approach to Drug Therapy

The study suggests that the patient's ADRs may have been influenced by drug-drug-gene interactions. The pharmacogenomic findings revealed that the patient carried genetic variations in drug-metabolizing enzymes, which could have led to increased drug bioavailability and prolonged drug exposure. This case report highlights the importance of considering pharmacogenomic factors when prescribing medications, particularly for patients taking multiple drugs.

Tailoring Treatment for Individual Needs

This case report emphasizes the need for a personalized approach to drug therapy, taking into account individual genetic variations and potential drug-drug-gene interactions. Pharmacogenomics offers a powerful tool for understanding how individuals respond to medications, minimizing the risk of ADRs and optimizing treatment outcomes.

Dr. Camel's Conclusion

The world of drug interactions can be a complex and unpredictable desert, filled with hidden dangers. This case report underscores the importance of understanding pharmacogenomics, like a trusted guide, to navigate this challenging landscape. By considering individual genetic variations, we can personalize drug therapy, minimizing risks and maximizing the benefits of treatment.

Date :
  1. Date Completed 2021-09-17
  2. Date Revised 2022-12-21
Further Info :

Pubmed ID

34187111

DOI: Digital Object Identifier

PMC8265195

SNS
PICO Info
in preparation
Languages

English

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