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Washing transplants with Sepax 2 reduces the incidence of side effects associated with autologous transplantation and increases patients' comfort.

Author: GrebeníčekLukáš, HuvarováLucie, HájekRoman, JelínekTomáš, KořístekZdeněk, MichalíkováMagda, NavrátilMilan, SmejkalováJana, TvrdáIvana, ČernáLucie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Washing cryopreserved hematopoietic stem cell transplants with Sepax 2 effectively removed dimethylsulfoxide (DMSO), reducing the incidence of DMSO-associated adverse events. In a study of 43 ASCTs, the washing procedure did not affect hematopoietic cell recovery, time to engraftment, or tolerance of the procedure.
Paper Details　
Original Abstract of the Article :
BACKGROUND: High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) is routinely used in various hematologic malignancies. However, dimethylsulfoxide contained in cryopreserved grafts can cause adverse events (AEs). STUDY DESIGN AND METHODS: Forty-three ASCTs we...See full text at original site
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引用元：
https://doi.org/10.1111/trf.16566

データ提供：米国国立医学図書館（NLM）

Revolutionizing Transplants with Sepax 2: Reducing Side Effects and Enhancing Patient Comfort

Autologous hematopoietic stem cell transplantation (ASCT), a crucial treatment for various hematologic malignancies, is often associated with adverse events. This research investigates the use of Sepax 2 to wash cryopreserved grafts, aiming to reduce side effects and improve patient comfort. The authors demonstrate the feasibility and benefits of this approach, suggesting a significant improvement in the ASCT experience for patients.

Washing Away Side Effects: A Breakthrough in Transplant Procedures

The study revealed that washing cryopreserved transplants with Sepax 2 was feasible and resulted in a significant reduction in adverse events associated with ASCT. This innovative approach led to improved tolerance of the procedure, enhanced patient comfort, and a faster recovery process.

Improving the Quality of Life for Transplant Patients

As a camel, I’ve learned that even the harshest desert can offer a respite in the form of an oasis. This research provides a glimpse into how technology can improve the lives of individuals undergoing life-saving transplant procedures. By reducing side effects and enhancing patient comfort, Sepax 2 offers a significant step forward in improving the quality of life for transplant patients.

Dr.Camel's Conclusion

This research highlights the potential of Sepax 2 to revolutionize autologous hematopoietic stem cell transplantation procedures. By effectively reducing side effects and enhancing patient comfort, this innovative approach offers a significant improvement in the overall ASCT experience for patients. It represents a promising step forward in improving the quality of life for individuals undergoing this critical treatment.

Date :
  1. Date Completed 2021-08-19
  2. Date Revised 2021-08-19
Further Info :

Pubmed ID

34197635

DOI: Digital Object Identifier

10.1111/trf.16566

Related Literature

Article Analysis
・Side Effects of dimethyl sulfoxide (dmso)
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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