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Cenobamate, a Sodium Channel Inhibitor and Positive Allosteric Modulator of GABA<sub>A</sub> Ion Channels, for Partial Onset Seizures in Adults: A Comprehensive Review and Clinical Implications.

Author: CornettElyse M, EdinoffAmber N, KayeAdam M, KayeAlan D, LatimerDustin R, PatelShaan B, PennyKayla M, RooneyKelsey C, RuffRachel D, SabbenahalliSuresh, UritsIvan, ViswanathOmar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This abstract discusses the potential of cenobamate, a newly approved drug for treating partial-onset seizures, in epilepsy management. Cenobamate's dual mechanism of action and low toxicity profile make it a promising addition to antiepileptic therapies.
Paper Details　
Original Abstract of the Article :
Medical management of epilepsy seeks to eliminate or to reduce the frequency of seizures, help patients maintain a normal lifestyle, and maintain psychosocial and occupational activities, while avoiding the negative side effects of long-term treatment. Current FDA approved drugs have been shown to h...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293325/

データ提供：米国国立医学図書館（NLM）

Cenobamate: A New Oasis in Epilepsy Treatment

The [treatment of epilepsy] is a long and arduous journey through the [desert of neurological disorders]. [Current antiepileptic drugs] often provide [limited relief] and come with [unwanted side effects]. This comprehensive review explores the potential of [cenobamate], a [newly-approved drug] for [partial-onset seizures]. Cenobamate offers a unique approach by [acting on two proposed mechanisms associated with epilepsy] - [positive allosteric modulation of GABAA ion channels] and [inhibition of voltage-gated sodium channels].

Cenobamate: A Promising Treatment Option

This review highlights the [potential benefits] of [cenobamate] in [treating partial-onset seizures]. Clinical trials have shown [promising results] in terms of [seizure reduction] and [tolerability].

Navigating the Desert of Epilepsy: Considerations for Patients

This review provides valuable insights into [cenobamate] as a [potential treatment option] for patients with [partial-onset seizures]. However, it's important to [discuss the potential risks and benefits] with your doctor to determine if [cenobamate] is right for you.

Dr.Camel's Conclusion

The desert of epilepsy can feel vast and unforgiving. This review explores a [new oasis] in the form of cenobamate. While further research is needed, this drug offers [hope for a better future] for patients seeking [effective and well-tolerated treatment] for their [seizure disorders].

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-07-23
Further Info :

Pubmed ID

34207493

DOI: Digital Object Identifier

PMC8293325

Related Literature

Article Analysis
・Side Effects of cenobamate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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