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Loperamide: a review of its pharmacological properties and therapeutic efficacy in diarrhoea.

Author: AveryG S, BrogdenR N, HeelR C, SpeightT M

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Loperamide, a butyramide derivative, is effective for symptomatic control of both acute and chronic diarrhea. It is more rapid and longer-lasting than diphenoxylate in acute diarrhea. Loperamide has been used for up to 3 years for chronic diarrhea without evidence of tolerance.
Paper Details　
Original Abstract of the Article :
Loperamide, a butyramide derivative is a new agent for use in symptomatic control of acute non-specific diarrhoea and chronic diarrhoea. Unlike diphenoxylate or codeine, loperamide does not appear to exert opiate activity in man at normal therapeutic doses. In acute diarrhoea, loperamide provides mo...See full text at original site
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引用元：
https://doi.org/10.2165/00003495-197815010-00003

データ提供：米国国立医学図書館（NLM）

Loperamide: A Versatile Tool for Diarrheal Relief

The management of [diarrhea] is a common concern in healthcare. This review examines the pharmacological properties and therapeutic efficacy of [loperamide] in treating diarrhea. The authors highlight the [effectiveness of loperamide in controlling both acute and chronic diarrhea] and discuss its advantages over other antidiarrheal agents like diphenoxylate and codeine. Key findings include [the rapid onset of action of loperamide], its [long duration of effect], and its [lack of opiate activity at therapeutic doses]. This research provides valuable insights into the use of loperamide in managing diarrhea.

A Journey Through the Digestive Desert: Finding Relief from Diarrhea

This review explores the [effectiveness of loperamide] in treating diarrhea, offering a valuable resource for understanding its [pharmacological properties] and [clinical applications]. The authors note that [loperamide provides more rapid control of symptoms than diphenoxylate] and offers a [longer duration of effect] than other antidiarrheal agents. This research emphasizes the importance of [choosing the right medication] for the specific type of diarrhea and [working with healthcare providers] to determine the best course of treatment.

A Sandcastle of Diarrhea Management: Building a Plan for Relief

This review provides valuable insights into the [management of diarrhea]. Understanding the [effectiveness of loperamide] and its advantages over other antidiarrheal agents can empower individuals to [make informed decisions about their healthcare] and to [seek appropriate medical attention] for persistent or severe diarrhea. This research underscores the importance of [working with healthcare providers] to develop a personalized treatment plan for diarrhea.

Dr.Camel's Conclusion

This review highlights the versatile nature of loperamide in managing both acute and chronic diarrhea. Its rapid onset of action, long duration of effect, and lack of opiate activity make it a valuable tool for controlling diarrheal symptoms and improving patient comfort.

Date :
  1. Date Completed 1978-04-26
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

342229

DOI: Digital Object Identifier

10.2165/00003495-197815010-00003

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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