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Formulation development of anti-stress compressed lozenges using a fractional factorial Latin cube design and ANOVA approach.

Author: KolisnykTetiana, RubanLena, YakovenkoOleksii

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed anti-stress compressed lozenges containing glycine and magnesium citrate using the direct compression method. By using a fractional factorial Latin cube design, the optimal excipient composition was determined to include isomalt, copovidone, and glyceryl behenate. These lozenges showed sufficient pharmaco-technical properties, including mechanical strength and slow-dissolving behavior.
Paper Details　
Original Abstract of the Article :
The aim of this work was to develop anti-stress compressed lozenges containing 100 mg of glycine and 250 mg of magnesium citrate obtained by the direct compression method. To choose optimal excipient composition providing the sufficient pharmaco-technical properties of the tablet blend, mechanical s...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34237946

データ提供：米国国立医学図書館（NLM）

Anti-Stress Lozenges: A Formulation Development Study

This study focuses on the development of anti-stress compressed lozenges containing glycine and magnesium citrate. The research employed a fractional factorial Latin cube design and ANOVA approach to optimize the excipient composition and achieve desired tablet properties.

Optimizing Anti-Stress Lozenge Formulation

The study evaluated various excipients and their effects on the tablet's mechanical strength, disintegration time, and overall stability. The researchers identified key excipients, including isomalt, copovidone, and glyceryl behenate, as crucial for achieving the desired properties of the lozenges.

Developing Effective and Safe Anti-Stress Supplements

This research contributes to the development of safe and effective anti-stress supplements. The study highlights the importance of optimizing excipient composition and ensuring proper tablet properties for optimal performance and patient satisfaction.

Dr. Camel's Conclusion

This study demonstrates the successful development of anti-stress compressed lozenges using a systematic approach. The research highlights the importance of careful formulation design and validation to ensure product safety and efficacy, creating a potentially valuable tool for stress management.
Date :
  1. Date Completed 2021-07-12
  2. Date Revised 2021-07-12
Further Info :

Pubmed ID

34237946

DOI: Digital Object Identifier

127418

Related Literature

Article Analysis
・Effects of magnesium citrate
SNS
PICO Info
in preparation
Languages

English

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