Synthesis and Development of Indole Based 5-HT3 Receptor Antagonists as Anti-Emetic Drugs in Oncology: An Update.

Author: Corona-BecerrilDavid, Cuevas-YañezErick, García-ElenoMarco A, González-RivasNelly, López-ValdezL Germán, ReyesHoracio, Rivera-FonsecaJohana L, UnnamatlaM V Basavanag

Paper Details 
Original Abstract of the Article :
An important group of antiemetic drugs used in the treatment of nausea and vomiting after chemotherapy containing an indole moiety in their structures, working as 5- hydroxytryptamine type 3 serotonin receptor antagonist (5-HT3). This study focuses on compounds bearing an indole core that present a ...See full text at original site
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引用元:
https://doi.org/10.2174/0929867328666210708091134

データ提供:米国国立医学図書館(NLM)

Indole-Based 5-HT3 Receptor Antagonists: A Beacon of Hope in the Desert of Chemotherapy

Chemotherapy, a vital treatment for cancer, can have significant side effects, including nausea and vomiting. This research focuses on the development of indole-based 5-HT3 receptor antagonists, a class of drugs that effectively combat these debilitating side effects. The authors explore the synthesis, biological activity, and characteristics of these drugs, seeking to optimize their efficacy and minimize their adverse effects. This is like venturing into a challenging desert environment, seeking to identify and cultivate oases of relief from the harsh realities of chemotherapy.

A Beacon of Relief: Indole-Based Antagonists Offer Hope

The study highlights the promising potential of indole-based 5-HT3 receptor antagonists in reducing chemotherapy-induced nausea and vomiting. These drugs offer a valuable tool for improving the quality of life for cancer patients undergoing treatment. The research also emphasizes the importance of continuous research and development in this field, aiming to create even more effective and targeted antiemetic drugs. This is like searching for new sources of water and shade in the desert, continuously striving to improve the conditions for those traversing this challenging terrain.

Navigating the Desert of Chemotherapy: Easing the Journey

The research on indole-based 5-HT3 receptor antagonists offers hope for patients undergoing chemotherapy. These drugs can significantly alleviate the discomfort and distress associated with nausea and vomiting, making the treatment journey more tolerable. By understanding the mechanisms behind these drugs and continuing to refine their development, researchers are working to pave the way for a smoother and more manageable path through the desert of chemotherapy.

Dr.Camel's Conclusion

This research presents a valuable contribution to the development of antiemetics for cancer patients. Indole-based 5-HT3 receptor antagonists offer a promising solution for reducing chemotherapy-induced nausea and vomiting, making a challenging journey more manageable and improving the quality of life for patients. The ongoing research in this field holds great promise for further advancements, ultimately leading to more effective and personalized treatments.

Date :
  1. Date Completed 2022-01-06
  2. Date Revised 2022-01-06
Further Info :

Pubmed ID

34238146

DOI: Digital Object Identifier

10.2174/0929867328666210708091134

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