Effects of Tamoxifen vs. Toremifene on fatty liver development and lipid profiles in breast Cancer.

Author: CaiYangjun, DiaoBiyu, HuXiaoqu, HuYingying, MiaoRongrong, SongDandan, ZengHanqian, ZhangBaodan, ZhangYuru

Paper Details 
Original Abstract of the Article :
Tamoxifen (TAM) and Toremifene (TOR), two kinds of selective estrogen receptor modulators (SERMs), have equal efficacy in breast cancer patients. However, TAM has been proved to affect serum lipid profiles and cause fatty liver disease. The study aimed to compare the effects of TAM and TOR on fatty ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272257/

データ提供:米国国立医学図書館(NLM)

Tamoxifen and Toremifene: Comparing Effects on Fatty Liver and Lipid Profiles in Breast Cancer Patients

Breast cancer, a prevalent and challenging disease, is often treated with selective estrogen receptor modulators (SERMs) like tamoxifen and toremifene. While both drugs demonstrate similar efficacy in breast cancer patients, concerns regarding the potential for tamoxifen to affect lipid profiles and induce fatty liver disease have arisen. This study, like a camel carefully comparing two different paths through the desert of breast cancer treatment, investigates the comparative effects of tamoxifen and toremifene on fatty liver development and lipid profiles in breast cancer patients.

SERMs: A Tale of Two Paths

The study found that while tamoxifen has been associated with adverse lipid profiles and fatty liver disease, toremifene may offer a potentially safer alternative in terms of its impact on lipid profiles and liver health. The study's findings suggest that toremifene may be a more favorable option for breast cancer patients who require SERM therapy, potentially minimizing the risk of developing fatty liver disease and other lipid-related complications.

Breast Cancer Treatment: Balancing Efficacy and Safety

This study highlights the importance of considering the potential side effects of medications, even those with proven efficacy in treating breast cancer. The findings suggest that toremifene may offer a more favorable safety profile compared to tamoxifen, emphasizing the need for personalized treatment plans that balance efficacy with patient safety.

Dr.Camel's Conclusion

The desert of breast cancer treatment is vast and complex, with many different paths to explore. This study provides valuable insights into the comparative safety profiles of tamoxifen and toremifene, highlighting the importance of carefully considering the potential side effects of medications and choosing the most appropriate treatment option for each individual patient.

Date :
  1. Date Completed 2021-11-01
  2. Date Revised 2021-11-01
Further Info :

Pubmed ID

34246237

DOI: Digital Object Identifier

PMC8272257

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English

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