Computational drug repurposing study of antiviral drugs against main protease, RNA polymerase, and spike proteins of SARS-CoV-2 using molecular docking method.

Author: FarahmandBehrokh, FatahiniaForoozan, IsmailzadehNarges, JalalvandAlireza, KhatouniSomayeh Behjat, NajafiZahra Bahri

Paper Details 
Original Abstract of the Article :
The new Coronavirus (SARS-CoV-2) created a pandemic in the world in late 2019 and early 2020. Unfortunately, despite the increasing prevalence of the disease, there is no effective drug for the treatment. A computational drug repurposing study would be an appropriate and rapid way to provide an effe...See full text at original site
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引用元:
https://doi.org/10.1515/jbcpp-2020-0369

データ提供:米国国立医学図書館(NLM)

Drug Repurposing: A New Oasis in the Desert of COVID-19

The global pandemic of COVID-19 has been a formidable desert storm, prompting researchers to search for effective treatments. This research explores the potential of drug repurposing – a strategy that involves identifying existing drugs that can be used to treat new diseases – to combat COVID-19. The authors used computational molecular docking techniques to investigate the inhibitory potential of over 50 antiviral drugs against three key proteins of SARS-CoV-2, the virus responsible for COVID-19. This approach could accelerate the development of new therapies for COVID-19, offering a promising avenue for combating this global health crisis.

Drug Repurposing: A Speedier Route to COVID-19 Therapies

This research showcases the promise of drug repurposing as a rapid and efficient approach to developing treatments for COVID-19. By leveraging the knowledge and data from existing drugs, researchers can accelerate the drug development process and potentially identify effective therapies more quickly. This approach offers a beacon of hope in the ongoing battle against the COVID-19 pandemic.

The Promise of Computational Drug Repurposing

This study underscores the importance of computational drug repurposing as a powerful tool for accelerating drug development. By utilizing computer simulations, researchers can efficiently screen existing drugs for potential therapeutic applications. This approach could significantly reduce the time and resources needed to develop new treatments, offering a valuable strategy for addressing emerging health challenges.

Dr.Camel's Conclusion

This study provides a glimmer of hope in the midst of the COVID-19 desert storm. Drug repurposing, a strategy that involves adapting existing drugs for new uses, offers a potential oasis of treatment options. By leveraging computational methods, researchers can rapidly identify effective therapies, potentially leading to faster and more efficient solutions for combating this global health crisis.

Date :
  1. Date Completed 2022-02-09
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

34265888

DOI: Digital Object Identifier

10.1515/jbcpp-2020-0369

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Languages

English

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