Paper Details 
Original Abstract of the Article :
Exemestane is an irreversible steroidal aromatase inhibitor, typically used to treat breast cancer. As an anti-tumor drug, exemestane has more obvious side effects on the gastrointestinal tract. The purpose of this work is to investigate the combination of exemestane with three important digestive e...See full text at original site
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引用元:
https://doi.org/10.1016/j.ijbiomac.2021.07.079

データ提供:米国国立医学図書館(NLM)

Exemestane and Digestive Enzymes: Exploring the Interaction

Exemestane is a widely used drug for treating breast cancer, but like a traveler encountering a harsh desert environment, it can have side effects on the gastrointestinal system. This study investigates the interaction between exemestane and three key digestive enzymes: pepsin, trypsin, and α-chymotrypsin.

Unraveling the Interaction: Exemestane and Digestive Enzymes

The study uses a combination of multi-spectroscopy and molecular docking techniques to analyze the interaction between exemestane and digestive enzymes. The findings reveal that exemestane forms stable complexes with these enzymes, potentially affecting their activity. This is like a traveler encountering a sandstorm, where the wind's force influences the path and behavior of the journey.

Understanding Gastrointestinal Side Effects

This research provides valuable insights into the mechanism of gastrointestinal side effects associated with exemestane. The study's findings help to better understand the interplay between drugs and digestive enzymes, crucial for developing strategies to mitigate potential side effects and improve patient outcomes. Just as a camel caravan needs to adapt to the changing conditions of the desert, healthcare professionals need to stay informed about the potential impacts of medications on the body.

Dr. Camel's Conclusion

This study delves into the intriguing world of drug-enzyme interactions, exploring the potential impact of exemestane on digestive enzymes. The findings highlight the importance of understanding the mechanisms behind gastrointestinal side effects, guiding the development of strategies to minimize these challenges and optimize patient care. This research, like a skilled desert guide, sheds light on the complexities of the human body and helps us navigate the path to better health outcomes.

Date :
  1. Date Completed 2021-12-20
  2. Date Revised 2021-12-20
Further Info :

Pubmed ID

34274402

DOI: Digital Object Identifier

10.1016/j.ijbiomac.2021.07.079

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SNS
PICO Info
in preparation
Languages

English

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