Paper Details

  1. Home
  2. Paper Details

Naldemedine Improves Patient-Reported Outcomes of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain in the COMPOSE Phase 3 Studies.

Author: CamilleriMichael, HaleMartin, MorlionBart, TackJan, WebsterLynn, WildJames

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This analysis evaluated the effect of naldemedine 0.2 mg on patient-reported outcomes in three phase 3 clinical studies. Naldemedine is a peripherally acting mu-opioid receptor antagonist, indicated for the treatment of opioid-induced constipation in patients with chronic non-cancer pain.
Paper Details　
Original Abstract of the Article :
Opioid-induced constipation is among the most common side effects associated with opioid use in patients with chronic non-cancer pain, and it can have a significant negative impact on health-related quality of life (QOL). This analysis evaluated the effect of naldemedine 0.2 mg on patient-reported o...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291809/

データ提供：米国国立医学図書館（NLM）

Naldemedine: A Promising Solution for Opioid-Induced Constipation

Opioid-induced constipation (OIC) can significantly impact the quality of life for patients with chronic non-cancer pain. This research evaluates the efficacy of naldemedine in alleviating OIC symptoms, providing valuable insights into patient-reported outcomes. The authors demonstrate the potential of naldemedine as a safe and effective treatment for OIC, improving patient well-being and reducing the burden of this debilitating side effect.

A Step Towards Improved Opioid Management

The study's findings are promising, demonstrating the potential of naldemedine to improve patient-reported outcomes in OIC. The results underscore the need for effective management of opioid-related side effects to enhance the overall quality of life for patients with chronic non-cancer pain. This research offers hope for a more comfortable and manageable experience for patients reliant on opioid therapy.

Navigating the Opioid Landscape

This research highlights the importance of addressing the multifaceted challenges associated with opioid use. It emphasizes the need for effective treatment options for OIC and other opioid-related side effects, while also advocating for a multidisciplinary approach to opioid management. This research serves as a reminder that there are ongoing efforts to improve patient care and minimize the negative consequences associated with opioid therapy.

Dr. Camel's Conclusion

This research highlights the potential of naldemedine as a valuable tool in managing OIC. The authors' findings demonstrate the drug's ability to improve patient-reported outcomes, offering hope for a more comfortable and manageable experience for patients with chronic non-cancer pain. This research underscores the importance of continued efforts to develop effective treatments and address the complex challenges associated with opioid use.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-25
Further Info :

Pubmed ID

34295186

DOI: Digital Object Identifier

PMC8291809

Related Literature

Article Analysis
・Side Effects of naldemedine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.