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Liver Transplantation for Non-Resectable Liver Metastases from Colorectal Cancer: A Systematic Review and Meta-Analysis.

Author: BaltatzisMinas, DavéMadhav, MobarakShahd, SatyadasThomas, StottMartyn C, TaraziMunir, VarleyRebecca

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study compared the current evidence for liver transplantation for non-resectable colorectal liver metastases (NRCLM) with the current standard treatment of palliative chemotherapy. Historically, colorectal liver metastases were considered a contraindication to liver transplantation. However, advancements in liver transplantation (LT) and dismal outcomes for those with metastatic colorectal cancer have led to a renewed interest in the topic.
Paper Details　
Original Abstract of the Article :
Colorectal liver metastases were historically considered a contraindication to liver transplantation, but dismal outcomes for those with metastatic colorectal cancer and advancements in liver transplantation (LT) have led to a renewed interest in the topic. We aim to compare the current evidence for...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476371/

データ提供：米国国立医学図書館（NLM）

Liver Transplantation for Colorectal Liver Metastases: A Complex Decision

The field of liver transplantation is facing a critical question: should liver transplantation be considered for patients with non-resectable colorectal liver metastases (NRCLM)? This systematic review and meta-analysis delves into the evidence, comparing the outcomes of liver transplantation with standard palliative chemotherapy for patients with NRCLM. The authors provide a comprehensive overview of the current state of knowledge, guiding clinicians in making informed decisions for their patients.

Weighing the Options: Liver Transplantation vs. Chemotherapy

This systematic review provides a valuable comparison of liver transplantation and palliative chemotherapy for patients with NRCLM. The analysis highlights the need for a careful assessment of individual patient factors, including tumor characteristics, overall health status, and access to specialized care. The review underscores the importance of a multidisciplinary approach to decision-making, involving surgeons, oncologists, and transplant specialists.

Navigating the Complexities of NRCLM: A Call for Individualized Care

This research sheds light on the complex decision-making process for patients with NRCLM. It's a reminder that every patient is unique and requires an individualized treatment plan. The review emphasizes the importance of careful consideration of all available treatment options, including the risks and benefits of each, to ensure the best possible outcome for each patient.

Dr. Camel's Conclusion

This research is a map guiding us through the intricate landscape of NRCLM treatment. It's a reminder that navigating this complex terrain requires careful consideration, a multidisciplinary approach, and a commitment to providing individualized care. It's a testament to the ongoing quest for innovative and compassionate solutions in the field of liver transplantation.

Date :
  1. Date Completed 2021-11-01
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

34322717

DOI: Digital Object Identifier

PMC8476371

Related Literature

Article Analysis
・Effective treatment of liver transplantation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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