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A systems-level study reveals host-targeted repurposable drugs against SARS-CoV-2 infection.
Author: ArditiMoshe, ArumugaswamiVaithilingaraja, BaharIvet, ChanStephen Y, ChenFangyuan, ChengMary Hongying, GarciaGustavo, GomezAngela C, LiuBing, PeiFen, PorrittRebecca A, SchurdakMark E, ShiQingya, SternAndrew M, TaylorD Lansing, VogtAndreas
Original Abstract of the Article :
Understanding the mechanism of SARS-CoV-2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharmacology approach, we identified a set of repurposable and investigational drugs as potential therapeutics against COVID-19. These were deduced from the...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328275/
データ提供:米国国立医学図書館(NLM)
Fighting COVID-19: Repurposing Drugs for a Global Challenge
This research explores the [virology] and [pharmacology] realms, investigating potential therapeutic approaches for COVID-19 by repurposing existing drugs. Using a [quantitative systems pharmacology] approach, the researchers identified a set of drugs that could potentially inhibit SARS-CoV-2 infection. They analyzed gene expression changes in infected cells and prioritized drugs based on their ability to interfere with viral-host interactions. Their findings offer a promising avenue for developing new treatment options for COVID-19.
Repurposing Drugs: A Strategic Approach to Pandemic Response
The researchers' discovery of repurposable drugs with potential antiviral activity against SARS-CoV-2 is a significant breakthrough. This strategy offers a faster path to developing new treatments, potentially accelerating the response to pandemics. By repurposing existing drugs, researchers can leverage existing knowledge and safety data, reducing the time and cost associated with drug development. This approach could have significant implications for future pandemic preparedness, allowing for a more rapid response to emerging viral threats.
Navigating the Pandemic: A Collective Effort
The COVID-19 pandemic has underscored the importance of global collaboration in research and development. Just as the desert camel navigates its challenging environment by relying on its instincts and learned knowledge, we too must work together to navigate the complexities of pandemics. The research on repurposing drugs highlights the power of collaborative efforts in finding solutions to global health challenges. By sharing knowledge, expertise, and resources, we can accelerate the development of new therapies and protect our communities from the devastating effects of infectious diseases.
Dr. Camel's Conclusion
This research is a testament to the power of scientific innovation and collaboration in the face of global challenges. Just as the desert camel navigates the sands with unwavering determination, we too must strive to conquer the challenges of pandemics through our collective efforts. By repurposing existing drugs and sharing knowledge, we can chart a path towards a healthier future.
Date :
- Date Completed 2021-08-16
- Date Revised 2023-03-15
Further Info :
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