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The role of anti-inflammatory drugs and nanoparticle-based drug delivery models in the management of ischemia-induced heart failure.

Author: AlmasTalal, AzharMaimoona, CheemaFaisal Habib, HaleyKathryn E, HameedAamir, ShaikhShan, ShoarSaeed

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review explores the potential of targeted myocardial delivery of anti-inflammatory drugs for treating post-MI heart failure. It examines the feasibility of using biodegradable polymers, liposomes, hydrogels, and nanoparticle-based drug delivery models (NDDM) to deliver these agents directly to the myocardium. The review highlights the challenges and future directions for developing effective NDDM-mediated treatments for ischemic heart failure.
Paper Details　
Original Abstract of the Article :
Ongoing advancements in the treatment of acute myocardial infarction (MI) have significantly decreased MI related mortality. Consequently, the number of patients experiencing post-MI heart failure (HF) has continued to rise. Infarction size and the extent of left ventricular (LV) remodeling are larg...See full text at original site
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引用元：
https://doi.org/10.1016/j.biopha.2021.112014

データ提供：米国国立医学図書館（NLM）

Fighting Heart Failure: A New Frontier in Anti-Inflammatory Drug Delivery

The [cardiovascular field] is continuously evolving, with new breakthroughs in the treatment of [ischemia-induced heart failure]. This study explores the potential of [targeted drug delivery] using [nanoparticle-based models] to deliver [anti-inflammatory drugs] directly to the [myocardium]. The researchers review [pre-clinical and clinical models] and discuss the challenges and opportunities associated with this approach. Their findings suggest that [localized delivery of anti-inflammatory agents] could be a promising strategy for improving the treatment of [ischemic heart failure].

Nanoparticles: Tiny Soldiers in the Battle Against Heart Failure

This study highlights the exciting potential of [nanoparticle-based drug delivery] in the fight against [ischemic heart failure]. By delivering [anti-inflammatory drugs] directly to the [myocardium], we can potentially reduce [infarction size], minimize [left ventricular remodeling], and ultimately improve patient outcomes. This innovative approach offers a glimpse into a future where [nanotechnology] plays a pivotal role in treating [cardiovascular diseases].

Precision Medicine: A Journey Through the Cardiac Desert

This research reflects the evolving landscape of [precision medicine] in the [cardiovascular field]. By targeting specific areas of the [heart] with [anti-inflammatory drugs], we can potentially achieve more effective treatment with fewer side effects. It's like using a compass to navigate the vast desert of the [cardiovascular system], guiding us toward more precise and targeted therapies.

Dr.Camel's Conclusion

The potential of [nanoparticle-based drug delivery] to revolutionize the treatment of [ischemic heart failure] is truly exciting. This research opens up new avenues for [precision medicine] in the [cardiovascular field], offering hope for a brighter future for patients battling this debilitating condition. It's a reminder that even in the seemingly endless desert of [cardiovascular disease], innovation and ingenuity can lead us to new oases of hope and healing.

Date :
  1. Date Completed 2021-12-23
  2. Date Revised 2021-12-23
Further Info :

Pubmed ID

34391184

DOI: Digital Object Identifier

10.1016/j.biopha.2021.112014

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Languages

English

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