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Pretomanid for tuberculosis: a systematic review.

Author: DecrooTom, GilsTinne, LynenLutgarde, Van DeunArmand, de JongBouke C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Pretomanid, a novel anti-tuberculosis drug, shows promise for treatment of rifampicin-resistant and highly resistant tuberculosis. Studies demonstrate efficacy in early bactericidal activity, bactericidal activity, and end-of-treatment outcomes. However, serious hepatotoxic adverse events have been reported, including three deaths.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Outcomes of treatment of tuberculosis patients with regimens including pretomanid have not yet been systematically reviewed. OBJECTIVES: To appraise existing evidence on efficacy and safety of pretomanid in tuberculosis. DATA SOURCES: Pubmed, clinicaltrials.gov. and Cochrane library. ...See full text at original site
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引用元：
https://doi.org/10.1016/j.cmi.2021.08.007

データ提供：米国国立医学図書館（NLM）

Pretomanid: A Promising Weapon Against Tuberculosis

Tuberculosis (TB), a persistent and deadly infectious disease, continues to pose a significant challenge to global health. This study examines the efficacy and safety of pretomanid, a novel drug, in the treatment of TB. The researchers embark on a comprehensive review of existing data, analyzing the potential of pretomanid as a valuable addition to the arsenal of anti-TB medications.

Their review reveals promising findings, suggesting that pretomanid holds significant potential in the treatment of both rifampicin-susceptible and highly resistant TB. The researchers highlight pretomanid's effectiveness in achieving early bactericidal activity, its contribution to favorable end-of-treatment outcomes, and its potential for minimizing the development of drug resistance.

A New Frontier in TB Treatment

The study's findings suggest that pretomanid has the potential to revolutionize TB treatment, providing a powerful new weapon against this persistent adversary. It offers hope for individuals struggling with drug-resistant forms of TB, a group that has often been underserved by existing treatments.

Fighting TB with Innovation

The development of pretomanid represents a significant advancement in TB treatment. It offers hope for improved outcomes for patients with both drug-susceptible and drug-resistant forms of TB, potentially leading to a more effective and sustainable approach to managing this global health threat.

Dr.Camel's Conclusion

This review highlights the promise of pretomanid as a potential game-changer in the fight against TB. Its effectiveness against both rifampicin-susceptible and highly resistant forms of the disease offers hope for improved treatment outcomes and potentially better patient outcomes. The journey toward a world free of TB continues, and this study serves as a beacon of hope, illuminating a path toward a more effective and sustainable approach to managing this global health challenge.

Date :
  1. Date Completed 2022-01-11
  2. Date Revised 2022-01-11
Further Info :

Pubmed ID

34400340

DOI: Digital Object Identifier

10.1016/j.cmi.2021.08.007

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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