Paper Details

  1. Home
  2. Paper Details

Intradermal, subcutaneous or intramuscular administration of hepatitis B vaccine: side effects and antibody response.

Author: HermodssonS, WahlM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Intradermal administration of a hepatitis B vaccine was as effective as intramuscular administration at a 10 times lower dose. The subcutaneous route was significantly less effective.
Paper Details　
Original Abstract of the Article :
The immune response after vaccination with a plasma-derived hepatitis B unit vaccine (MSD) administered intradermally or subcutaneously in 2 microgram doses was compared to the recommended 20 microgram dose administered intramuscularly. The trial was performed in 58 healthy volunteers 20-43 (mean 30...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3109/00365548709117195

データ提供：米国国立医学図書館（NLM）

Hepatitis B Vaccine: Administration Routes and Immune Response

This research investigates the [optimal route of administration for the hepatitis B vaccine], exploring its impact on [immune response and side effects]. It compares the [intradermal, subcutaneous, and intramuscular routes] of administration, focusing on the [dosage required for effective seroconversion] and the [incidence of adverse reactions]. The authors found that [intradermal administration with a reduced dose of 2 micrograms resulted in comparable seroconversion rates to intramuscular administration with a standard dose of 20 micrograms] while significantly reducing the frequency of local side effects. The study emphasizes the potential of [intradermal administration] to improve the [acceptability and accessibility of the hepatitis B vaccine] in various settings.

Navigating the Desert of Vaccination

This research highlights the importance of [optimizing vaccine delivery] to maximize effectiveness and minimize side effects. Just as a skilled traveler chooses the most efficient route across a desert, researchers are continually seeking ways to improve the delivery of vaccines to ensure optimal protection and minimize the discomfort associated with vaccination.

Improving Global Health Through Efficient Vaccine Delivery

The study encourages further research and innovation in [vaccine delivery strategies] to improve the [global health impact of vaccination programs]. Imagine a camel caravan efficiently transporting vaccines across a vast desert landscape, reaching remote communities and protecting them from disease. Similarly, we must strive for efficient vaccine delivery strategies to ensure equitable access and protection for all.

Dr.Camel's Conclusion

This research, like a trailblazer navigating the vast desert of [vaccination], sheds light on the potential of intradermal administration for improving the delivery of the hepatitis B vaccine. The findings encourage us to explore innovative approaches to vaccine delivery, ensuring wider access and protection for all, particularly in resource-limited settings.

Date :
  1. Date Completed 1988-04-18
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

3441747

DOI: Digital Object Identifier

10.3109/00365548709117195

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.