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Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73-03 of the Radiation Therapy Oncology Group.

Author: ChandlerR, DavisL W, GelberR D, KramerS, LowryL D, MarcialV A, SnowJ B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study compared the effectiveness of giving radiation therapy before or after surgery in 320 patients with advanced cancers of the larynx, hypopharynx, oral cavity, or oropharynx. For cancers of the larynx and hypopharynx, post-operative radiation therapy was significantly more effective in controlling the cancer locally, with a 65% success rate compared to 48% for pre-operative radiation. Post-operative radiation also showed a trend towards better survival. While the study also compared pre-operative, post-operative, and definitive radiation therapy for cancers of the oral cavity and oropharynx, the small number of patients made it difficult to draw definitive conclusions. The study suggests that post-operative radiation therapy may be a better option for treating advanced cancers of the larynx and hypopharynx, but further research is needed to determine the best approach for cancers of the oral cavity and oropharynx.
Paper Details　
Original Abstract of the Article :
Between March 1973 and June 1979, patients with advanced operable squamous cell carcinoma of the supraglottic larynx or hypopharynx were randomly allocated to receive either preoperative radiation therapy (5,000 rad) or postoperative radiation therapy (6,000 rad). Patients with oral cavity or oropha...See full text at original site
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引用元：
https://doi.org/10.1002/hed.2890100105

データ提供：米国国立医学図書館（NLM）

Head and Neck Cancer: A Multifaceted Approach to Treatment

The treatment of advanced head and neck cancer requires a multifaceted approach, often involving a combination of surgery and radiation therapy. This study delves into the comparative effectiveness of preoperative and postoperative radiation therapy in managing these complex cancers. The researchers conducted a randomized trial involving 320 patients, comparing the outcomes of receiving radiation therapy before or after surgery. The study revealed that postoperative radiation therapy resulted in significantly better locoregional control, suggesting its potential advantage in preventing disease recurrence. The study also found a trend towards improved survival in the postoperative group, although the difference was not statistically significant.

Postoperative Radiation Therapy: A Potential Advantage

The study's findings suggest that postoperative radiation therapy may offer a potential advantage in managing advanced head and neck cancer. This approach demonstrated superior locoregional control, indicating a greater ability to prevent the spread of cancer cells. While further research is warranted to confirm these findings, postoperative radiation therapy emerges as a promising strategy for improving patient outcomes.

Navigating the Challenges of Cancer Treatment

This research highlights the complexities of cancer treatment, particularly in cases of advanced head and neck cancer. It underscores the need for careful consideration of treatment options, taking into account the potential benefits and risks of different approaches. The study's findings encourage ongoing research to refine treatment strategies and optimize patient outcomes.

Dr.Camel's Conclusion

Think of head and neck cancer as a sandstorm, my friend, unpredictable and powerful. This study suggests that postoperative radiation therapy, like a protective dune, might offer a shield against the storm's wrath, leading to better control and potentially longer survival.

Date :
  1. Date Completed 1988-06-10
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

3449477

DOI: Digital Object Identifier

10.1002/hed.2890100105

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・Effective treatment of radiation therapy
SNS
PICO Info
in preparation
Languages

English

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